cruza – -Translation – Keybot Dictionary

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  BRC  
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A mikrofluidika alapvető a baktérium kolóniák vizsgálatában is, új irányzatot képvisel e területen Galajda Péter csoportja. Kutatásaik alapkoncepciója a baktériumok szociális élete, kommunikációjuk, illetve a környezet térbeli és időbeli szerkezetének szerepe a baktérium kolóniák életére.
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Microfluidics is also a crucial technique for us to study bacterial populations, a new direction in our institute initiated by Péter Galajda. The fundamental concept of their research concerns the social life, the communication and pattern formation of bacteria, as well as the role of the spatial and temporal structure of the environment.
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A Laboratóriumban csúcs technológiát képviselő lézer-pásztázó konfokális mikroszkóp, fluoreszcens sztereo mikroszkóp és valósidejű élősejt-analízist lehetővé tevő mikroszkópos állomás működik. Ezekkel a modern műszerekkel például háromdimenziós fehérje lokalizációt, mobilitás vizsgálatot és időbeli dinamikai analízist lehet elvégezni élő sejtekben, szövetekben, szervekben.
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Our modern imaging center is equipped with state-of-the-art confocal laser scanning microscopes, fluorescence and stereo microscopes, two photon microscope, laser microdissection microscope and powerful image analysis computers with professional 3D imaging software (Huygens Professional by Scientific Volume Imaging).
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Az eukarióta sejtciklus szabályozásában jelentős szerepe van az ubikvitin-proteaszóma rendszer (UPS) által koordinált fehérjelebontásnak. A fehérjelebontás irreverzibilis természete biztosítja a sejtciklus egyirányúságát, és ez teszi lehetővé a sejtfolyamatok tér és időbeli összehangolását is.
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Orderly and timely progression through the cell division cycle is essential to maintain genome stability in eukaryotes. Errors in this process alter gene dosage and can result in developmental defects or cancer. Key transitions in the eukaryotic cell cycle are regulated through intracellular proteolysis by the ubiquitin-proteasome system (UPS). Due to the irreversible nature of protein degradation, by sequentially removing regulators, this process generates directionality in the cell cycle and ensures proper timing and coordination of events. Degradation of proteins by the ubiquitin-mediated protein degradation involves two successive steps: tagging of substrate proteins by the covalent attachment of polyubiquitin chains and the subsequent degradation of the tagged protein by the 26S proteasome. Besides the ubiquitin conjugating pathway and the 26S proteasome, additional factors like deubiquitylating enzymes (DUBs) and polyubiquitin binding proteins (UBPs) are involved in the efficient degradation of target proteins.
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Mikroszkópos Sejtanalízis Laboratóriumunkban csúcstechnológiai lézer-pásztázó konfokális mikroszkópok, fluoreszcens és sztereo mikroszkópok, valósidejű élősejt-analízist lehetővé tevő mikroszkópos állomás, kétfoton mikroszkóp és lézer mikrodisszekciós mikroszkóp található. Ezekkel a modern műszerekkel többek között háromdimenzióban fehérje lokalizációt és mobilitás vizsgálatot, valamint időbeli dinamikai analízist végezhetünk élő sejtekben, szövetekben, szervekben.
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This ability to visualize the dynamics of proteins in vesicles, organelles, cells and tissue has begun to provide new insights into how cells function in health and disease. Such work yields unique mechanistic insight by directly illustrating the complex spatial-temporal dynamics of fundamental cellular processes such as mitosis, morphogenesis, polarization, embryonic development, membrane trafficking and cytoskeleton dynamics. Many of these processes are highly dynamic and are challenging to image by traditional means. In this aim, we are strongly committed to the development and application of optical imaging, fluorescent labeling and biochemical techniques that will enable us and others to understand the complex organization within and between cells.
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Érdeme, hogy kiterjedt nemzetközi kapcsolatai révén sikerült megszereznie 1973 és '77 között az SZBK-beli munka elkezdéséhez nélkülözhetetlen 1 millió 255 ezer dollár UNESCO-UNDP- támogatást, amely alapvetően három nagy célt szolgált.
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Naturally, the directors general of the Centre have left their fingerprints on the history of the BRC. The founder Director General, Brunó Straub F. (1970-1977) exerted a long-lasting influence upon the shaping of the image of the BRC. His intention that researchers working in different scientific fields but in the same facility should work mutually supporting one another has stood the test of time and proven an excellent and viable idea. It was owing to his extensive international relations that Brunó Straub F. could obtain the USD-1.255-million-support from UNESCO-UNDP that was indispensable in the period between 1973 and 1977 for work to start in the BRC. This funding served three fundamental purposes. It was used to cover the costs of the eminent scientific authorities arriving at the Centre from all over the world as advisors. It is also owing to the availability of this support that young Hungarian researchers made study visits abroad, in a combined period of 35 years. Thirdly, this funding enabled the purchasing of a state-of-the-art equipment pool for the BRC, which meets even Western European standards. It is to Brunó Straub F. that we owe thanks for the fact that, in spite of the status quo conservation approach of Hungary’s employment policies prevailing at the time, young researchers were contracted by the BRC for fixed periods and thus had to face regular challenges and appraisals. At the same time, this practice also made it possible for young researchers to leave their superior if they so decided and find a new leader – within the Centre. Though the continuation of this practice is now made difficult by the current funding application system, the spirit of Straub lives in and influences work at the Centre even today.