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An der Pathogenese von Asthma können mehrere Gene beteiligt sein, wobei bisher noch kein spezifisches Gen oder mehrere spezifische Gene mit Sicherheit identifiziert werden konnten. Der stärkste für Asthma prädisponierende Faktor ist eine Atopie, die bei etwa 30 bis 50 Prozent der Bevölkerung auftritt und durch die Bildung abnormer Mengen von IgE-Antikörpern gekennzeichnet ist.
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Risk factors can be distinguished in hereditary and acquired factors and factors triggering acute exacerbation. Hereditary factors correspond to a genetic predisposition determining the development of asthma or allergic sensitization. Multiple genes may be involved in the pathogenesis of asthma but no particular gene or genes have been identified with certainty yet. Atopy, defined as the production of abnormal amounts of IgE antibodies, occurs in 30 to 50 percent of the population and is the strongest predisposing factor for asthma. Another factor with heritable component is airway hyperresponsiveness. It is associated with airway inflammation and remodelling indicating that it may precede the development of asthma.
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Risk factors can be distinguished in hereditary and acquired factors and factors triggering acute exacerbation. Hereditary factors correspond to a genetic predisposition determining the development of asthma or allergic sensitization. Multiple genes may be involved in the pathogenesis of asthma but no particular gene or genes have been identified with certainty yet. Atopy, defined as the production of abnormal amounts of IgE antibodies, occurs in 30 to 50 percent of the population and is the strongest predisposing factor for asthma. Another factor with heritable component is airway hyperresponsiveness. It is associated with airway inflammation and remodelling indicating that it may precede the development of asthma.
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