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  Page 7 - Les toxines cy...  
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Ito, E., Kondo, F. et Harada, K.-I. Hepatic necrosis in aged mice by oral administration of microcystin-LR. Toxicon, 35(2): 231-239 (1997).
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Ito, E., Kondo, F. and Harada, K.-I. Hepatic necrosis in aged mice by oral administration of microcystin-LR. Toxicon, 35(2): 231-239 (1997).
  Sommaire de l'atelier d...  
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Le programme de recherche de M. Charbonneau est axé sur l'étude des mécanismes moléculaires et cellulaires des effets de l'hexachlorobenzène et d'autres polluants organiques persistants sur le développement du cancer du sein, et des mécanismes moléculaires et cellulaires du développement du cancer du foie induit par l'hexachlorobenzène et la microcystine-LR.
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Doctor Charbonneau received his Ph.D. in Pharmacology from the Université de Montréal and completed a post-doctoral fellowship at CIIT under the direction of Dr. James Swenberg. He is now a Professor of Toxicology at INRS-Institut Armand-Frappier, Université du Québec à Montréal and the Director of the Quebec Environmental Health Research Network, an arm of the Quebec Health Research Council (FRSQ). Doctor Charbonneau's current research program focuses on investigating the molecular and cellular mechanisms for the effects of hexachlorobenzene and other persistent organic pollutants on human breast cancer development and the molecular and cellular mechanisms of hexacholorobenzene and microcystin LR-induced liver cancer. He has also participated in a research project studying the toxicokinetics of acetaldehyde and ethanol after inhalation exposure in rats.
  Comité fédéral-provinci...  
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Le Secrétariat préparera un rapport sur les toxines cyanobactériennes pour la prochaine réunion afin de décrire l'état de la science et la possibilité d'utiliser une toxine autre que microcystine LR pour l'élaboration d'une recommandation.
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Secretariat to prepare report on cyanobacterial toxins for next meeting on the state of science and possibilities for using a toxin other than Microcystin LR for the basis of a guideline value, and to update WaterTalk on cyanobacteria.
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Ueno, Y., Makita, Y., Nagata, S., Tsutsumi, T., Yoshida, F., Tamura, S. -L. , Sekijima, M., Tashiro, F., Harada, T. et Yoshida, T. No chronic oral toxicity of a low dose of microcystin-LR, a cyanobacterial hepatotoxin, in female BALB-c mice. Environ.
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Ueno, Y., Makita, Y., Nagata, S., Tsutsumi, T., Yoshida, F., Tamura, S.-L., Sekijima, M., Tashiro, F., Harada, T. and Yoshida, T. No chronic oral toxicity of a low dose of microcystin-LR, a cyanobacterial hepatotoxin, in female BALB-c mice. Environ. Toxicol., 14(1): 45-55 (1999).
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Mackay, W.C. A preliminary study of microcystin-LR in dug-outs which supply water for domestic use in Northern Alberta --1997. Rapport final produit pour l'Administration du rétablissement agricole des Prairies, juin (1998).
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Mackay, W.C. A preliminary study of microcystin-LR in dug-outs which supply water for domestic use in Northern Alberta --1997. Final report prepared for the Prairie Farm Rehabilitation Administration, June (1998).
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Robinson, N.A., Pace, J.G., Matson, C.F., Miura, G.A. et Lawrence, W.B. Tissue distribution, excretion and hepatic biotrans-formation of microcystin-LR in mice. J. Pharmacol. Exp. Ther. , 256(1): 176-182 (1991).
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Robinson, N.A., Pace, J.G., Matson, C.F., Miura, G.A. and Lawrence, W.B. Tissue distribution, excretion and hepatic biotrans-formation of microcystin-LR in mice. J. Pharmacol. Exp. Ther., 256(1): 176-182 (1991).
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Meriluoto, J.A.O., Nygård, S.E., Dahlem, A.M. et Eriksson, J.E. Synthesis, organotropism and hepatocellular uptake of two tritium-labeled epimers of dihydromicrocystin-LR, a cyanobacterial peptide toxin analog.
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Meriluoto, J.A.O., Nygård, S.E., Dahlem, A.M. and Eriksson, J.E. Synthesis, organotropism and hepatocellular uptake of two tritium-labeled epimers of dihydromicrocystin-LR, a cyanobacterial peptide toxin analog. Toxicon, 28(12): 1439-1446 (1990).
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Nishiwaki, R., Ohta, T., Sueoka, E., Suganuma, M., Harada, K. -I. , Watanabe, M.F. et Fujiki, H. Two significant aspects of microcystin-LR: specific binding and liver specificity. Cancer Lett. , 83:283-289 (1994).
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Nishiwaki, R., Ohta, T., Sueoka, E., Suganuma, M., Harada, K.-I., Watanabe, M.F. and Fujiki, H. Two significant aspects of microcystin-LR: specific binding and liver specificity. Cancer Lett., 83:283-289 (1994).
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On a constaté que la microcystine-LR était un inhi-biteur puissant des protéines eucaryotes sérine/thréonine phosphatases 1 et 2A
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Microcystin-LR was found to be a potent inhibitor of eukaryotic protein serine/threonine phosphatases 1 and 2A both
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Mackay, W.C. Microcystin-LR levels in water supplies in the Peace River region, Alberta during 1998. Rapport final produit pour l'Administration du rétablissement agricole des Prairies, novembre (1998).
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Mackay, W.C. Microcystin-LR levels in water supplies in the Peace River region, Alberta during 1998. Final report prepared for the Prairie Farm Rehabilitation Administration, November (1998).
  Les toxines cyanobactér...  
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Les toxines cyanobactériennes -- Les microcystines-LR
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Cyanobacterial Toxins -- Microcystin-LR
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Fawell, J.K., Mitchell, R.E., Everett, D.J. et Hill, R.E. The toxicity of cyanobacterial toxins in the mouse: I microcystin-LR. Hum. Exp. Toxicol., 18(3): 162-167 (1999).
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Fawell, J.K., Mitchell, R.E., Everett, D.J. and Hill, R.E. The toxicity of cyanobacterial toxins in the mouse: I microcystin-LR. Hum. Exp. Toxicol., 18(3): 162-167 (1999).
  Les toxines cyanobactér...  
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Annexe A : Protocole séquentiel de détection de la microcystine-LR dans les approvisionnements d'eau servant à la consommation humaine
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Annex A: Stepwise Protocol for Microcystin-LR in Water Supplies Used for Human Consumption
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Ito, E., Kondo, F., Terao, K. et Harada, K.-I. Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin-LR. Toxicon, 35(9): 1453-1457 (1997).
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Ito, E., Kondo, F., Terao, K. and Harada, K.-I. Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin-LR. Toxicon, 35(9): 1453-1457 (1997).
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Jones, G., Gurney, S. et Rocan, D. Blue-green algae et microcystin-LR in surface water supplies of southwestern Manitoba. Manitoba Environment Report No. 98-06, Manitoba Environment. 82 pp. (1998).
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Jones, G., Gurney, S. and Rocan, D. Blue-green algae and microcystin-LR in surface water supplies of southwestern Manitoba. Manitoba Environment Report No. 98-06, Manitoba Environment. 82 pp. (1998).
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Kotak, B.G., Lam, A.K-Y., Prepas, E.E., Kenefick, S.L. et Hrudey, S.E. Variability of the hepatotoxin microcystin-LR in hyper-eutrophic drinking water lakes. J. Phycol., 31: 248-263 (1995).
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Kotak, B.G., Lam, A.K-Y., Prepas, E.E., Kenefick, S.L. and Hrudey, S.E. Variability of the hepatotoxin microcystin-LR in hyper-eutrophic drinking water lakes. J. Phycol., 31: 248-263 (1995).
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Robinson, N.A., Miura, G.A., Matson, C.F., Dinterman, R.E. et Pace, J.G. Characterization of chemically tritiated microcystin-LR and its distribution in mice. Toxicon, 27(9): 1035-1042 (1989).
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Robinson, N.A., Miura, G.A., Matson, C.F., Dinterman, R.E. and Pace, J.G. Characterization of chemically tritiated microcystin-LR and its distribution in mice. Toxicon, 27(9): 1035-1042 (1989).
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.97 ont signalé que la DL50de la microcystine-LR administrée par voie orale (gavage) (10,0 mg/kg p.c.) chez les souris âgées de six semaines était 167 fois plus élevée que la valeur intra-péritonéale (65,4 µg/kg p.c.).
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.97 reported that the LD50 for orally (gavage) administered (10.0 mg/kg bw) microcystin-LR in six-week-old mice was 167 times higher than the intraperitoneal value (65.4 µg/kg bw). Histologically, both routes of administration resulted in similar types of injuries to hepatocytes, including haemorrhage and necrosis.
  Page 4 - Comité fédéral...  
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La microcystine LR a été classée parmi les substances possiblement cancérogènes pour les humains.
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Microcystin-LR has been listed as a possible human carcinogen.
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Hart, J. et Stott, P. Microcystin-LR removal from water. Report FR0367, Foundation for Water Research, Marlow, UK (1993), cited in reference 7.
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Hart, J. and Stott, P. Microcystin-LR removal from water. Report FR0367, Foundation for Water Research, Marlow, UK (1993), cited in reference 7.
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Williams, D.E., Craig, M., Dawe, S.C., Kent, M.L., Holmes, C.F.B. et Andersen, R.J. Evidence for a covalently bound form of microcystin-LR in salmon liver et dungeness crab larvae. Chem. Res. Toxicol.
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Williams, D.E., Craig, M., Dawe, S.C., Kent, M.L., Holmes, C.F.B. and Andersen, R.J. Evidence for a covalently bound form of microcystin-LR in salmon liver and dungeness crab larvae. Chem. Res. Toxicol., 10: 463-469 (1997).
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MacKintosh, C., Beattie, K.A., Klumpp, S., Cohen, P. et Codd, G.A. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants.
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MacKintosh, C., Beattie, K.A., Klumpp, S., Cohen, P. and Codd, G.A. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett., 264(2): 187-192 (1990).
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Yoshida, T., Makita, Y., Nagata, S., Tsutsumi, T., Yoshida, F., Sekijima, M., Tamura, S. -I. et Ueno, Y. Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin, in mice. Nat. Toxins, 5: 91-95 (1997).
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Yoshida, T., Makita, Y., Nagata, S., Tsutsumi, T., Yoshida, F., Sekijima, M., Tamura, S.-I. and Ueno, Y. Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin, in mice. Nat. Toxins, 5: 91-95 (1997).
  Comité fédéral-provinci...  
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Le secrétariat fait une présentation sur l'utilisation des trousses d'analyse des microcystines pour le terrain. Les membres discutent si la microcystine-LR est la meilleure toxine à cibler.
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The Secretariat gave a presentation on the use of the field test kits for microcystins. Members discussed whether Microcystin-LR was the best toxin to target.
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Eriksson, J.E., Grönberg, L., Nygård, S., Slotte, J.P. et Meriluoto, J.A.O. Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin. Biochim. Biophys. Acta, 1025: 60-66 (1990).
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Eriksson, J.E., Grönberg, L., Nygård, S., Slotte, J.P. and Meriluoto, J.A.O. Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin. Biochim. Biophys. Acta, 1025: 60-66 (1990).
  Page 4 - Comité fédéral...  
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Microcystine LR :
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Microcystin-LR:
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Lambert, T.W., Holmes, C.F.B. et Hrudey, S.E. Adsorption of microcystin-LR by activated carbon and removal in full scale water treatment. Water Res., 30(6): 1411-1422 (1996).
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Lambert, T.W., Holmes, C.F.B. and Hrudey, S.E. Adsorption of microcystin-LR by activated carbon and removal in full scale water treatment. Water Res., 30(6): 1411-1422 (1996).
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Cousins, I.T., Bealing, D.J., James, H.A. et Sutton, A. Biodegradation of microcystin-LR by indigenous mixed bacterial populations. Water Res., 30(2): 481-485 (1996).
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Cousins, I.T., Bealing, D.J., James, H.A. and Sutton, A. Biodegradation of microcystin-LR by indigenous mixed bacterial populations. Water Res., 30(2): 481-485 (1996).
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Au cours d'une étude réalisée à Quintiles par le WRc au Royaume-Uni, on a administré de la microcys-tine-LR par voie orale, soit par gavage, à des groupes de 15 souris mâles et de 15 souris femelles, à raison de 0, 40, 200 ou 1 000 µg/kg p.c. par jour pendant 13 semai-nes.
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In a study conducted at Quintiles by WRc in the United Kingdom, microcystin-LR was administered orally by gavage to groups of 15 male and 15 female mice at 0, 40, 200 or 1000 µg/kg bw per day for 13 weeks. The no-observed-adverse-effect level (NOAEL) for liver toxicity was 40 µg/kg bw per day. At the next highest dose level, there was slight liver pathology in one male and two female mice. At the highest dose level, all mice showed liver changes, which included chronic inflammation, degeneration of hepatocytes and haemosiderin deposits. In male mice at the two highest dose levels, alanine and aspartate aminotransferases were significantly elevated, serum --glutamyl transferase was slightly reduced and there were small but significant reductions in total serum protein and serum albumin; alkaline phosphatase was also significantly increased at the highest dose. In female mice at the highest dose level, only increases in alkaline phosphatase and alanine aminotransferase were observed. Male mice exhibited reduced body weight gain in all treatment groups, but there was no dose-response relationship, and the final body weight was depressed by only 7%.94
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Fawell, J.K., James, C.P. et James, H.A. Toxins from blue-green algae: toxicological assessment of microcystin-LR and a method for its determination in water. Rapport No. FR 0359/2/DoE 3358/2, Water Research Centre, Medmenham, UK.
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Fawell, J.K., James, C.P. and James, H.A. Toxins from blue-green algae: toxicological assessment of microcystin-LR and a method for its determination in water. Report No. FR 0359/2/DoE 3358/2, Water Research Centre, Medmenham, UK. 46 pp. (1994).
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