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DNCB is usually applied in a diluted solution to a small patch of skin in decreasing doses over time, as the immune system becomes more responsive. Applying DNCB should produce redness, itchiness and perhaps even blisters or raised welts. These reactions are all signs that the immune system is responding. If the symptoms are too severe, a person usually switches to a more dilute dose. If there are no visible symptoms, a person may use a more concentrated solution. For most people, DNCB seems to have few side effects beyond the itching and discomfort where the chemical is applied. These symptoms can be treated with calamine lotion or other over-the-counter anti-itch creams. A small percentage of people have a severe reaction to DNCB and must discontinue use. DNCB can also make the spot on which it is applied more sensitive to the sun. A DNCB starter kit costs about $50 (US). DNCB is not regulated nor available in Canada.
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