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Because EWS-WT1 upregulates PDGF receptor, this compound is a rational drug to test for this disease.24,35 Sunitinib is a multikinase inhibitor that targets VEGFR 1, 2 and 3, PDGFR-α, PDGFR-ß, KIT, FLT-3, RET and CSF-1.

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Le traitement actuel des DSRCT est hautement toxique, il possède de nombreux effets secondaires et n’est pas suffisamment efficace. Des avancées récentes dans la physiopathologie moléculaire de la DSRCT devraient permettre le développement de thérapies ciblées efficaces et ayant des effets secondaires moindres. Par exemple un inhibiteur du récepteur de PDGF (platelet-derived growth factor) le leflunomide (SU101) agit en inhibant l’autophosphorylation du récepteur induite par le PDGF et la progression dans le cycle cellulaire qui s’ensuit. Ce composé inhibe également la dihydro-orotate dehydrogenase interférant ainsi avec la biosynthèse pyrimidique. Dans un essai de phase un dans lequel 2 des 27 patients inclus avaient une DSRCT, l’un d’entre eu a montré un ralentissement significatif de la progression de la maladie ainsi qu’une amélioration des symptômes associés (douleur). Puisque la protéine EWS-WT1 active le récepteur de PDGF, il semble que celui-ci soit une cible potentielle pour évaluer des nouvelles drogues (24 ; 35). Le sunitinib, un inhibiteur de multikinases, cible VEGFR1, 2 et 3, PDGFR-α, PDGFR-ß, KIT, FLT-3, RET et CSF-1. Au cours d’un essai récent, un patient ayant une DSRCT a reçu du sunitinib et a eu une maladie stable pendant 56 semaines avant que la maladie progresse à nouveau (36, 37). Les essais en cours qui évaluent des agents ciblant les voies de transduction de signalisation comprennent l’inmatinib mesylate (dans le but d’interférer avec la voie de signalisation du récepteur de PDGF) et l’AMG 479 (agent bloquant le récepteur d’IGF-1) (38-40). Il a été montré que les tumeurs réfractaires expriment fortement les récepteurs aux androgènes et dkit ; cependant, le potentiel thérapeutique de ces découvertes nécessite des investigations plus poussées (41).

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*; (Year: 2010). Title: Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model. Journal: Journal of Cellular and Molecular Medicine: Volume: 14 Issue: 6B, S-Page: 1857-E-Page: 1867 PubMed

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Autoren: Bergmann,A.; Ahmad,S.; Cudmore,M.; Gruber,A.D.; Wittschen,P.; Lindenmaier,Werner*; Christofori,G.; Gross,V.; Gonzalves,A.C.; Grone,H.J.; Ahmed,A.; Weich,Herbert A.*; (Jahr: 2010). Titel: Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model. Zeitschrift: Journal of Cellular and Molecular Medicine: Band: 14 Heft: 6B, S-Seite: 1857-E-Seite: 1867 PubMed

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Show textShow cached sourceOpen source URL	Full truck load (FLT) or part load (LTL), Ex Trans Cargo Inc. is committed to provide the best available alternatives to deliver your goods on time and cost-efficiently. Whether it is for a delivery to the next door or at the other end of the continent, your shipments are in good hands with our experienced team!
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Show textShow cached sourceOpen source URL	Two radiopharmaceuticals, [18F]FDG and [18F]FLT, showing as an example for molecular imaging a patient with an oropharynx CA. The differences of physiological uptake in brain (FDG) and bone marrow (FLT) are noteworthy.
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Show textShow cached sourceOpen source URL	The scientists used a modified constituent of our genetic information that is required for the division of cells and labelled it with a radioactive substance. Since leukaemia cells divide very rapidly, the marker 18F-fluorodeoxythymidine (18F-FLT) accumulates in leukaemia manifestation sites.
Compare text pagesCompare HTM pagesOpen source URLOpen target URLDefine bio-pro.de as primary domain	Die Wissenschaftler nutzten einen abgewandelten Grundbaustein unserer Erbinformation, der für die Zellteilung notwendig ist, und markierten ihn mit einer radioaktiven Substanz. Da Leukämiezellen sich besonders stark durch Zellteilung vermehren, sammelt sich die markierte Substanz (18F-Fluorodeoxythymidine, kurz 18F-FLT) dort, wo Leukämiezellen aktiv sind.

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Show textShow cached sourceOpen source URL	Soluble FLT-1 rules placental destiny, Yamashita, M.　Kumasawa, K.　Nakamura, H.　Kimura, T., Biochem Biophys Res Commun，496:1243-1249, 2018.02, Papers
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Show textShow cached sourceOpen source URL	Type: Type of observing platform: Stationary (STN) or Moving (e.g., Airborne (FLT), Ship borne (SHP), etc.). The default is STN.
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Show textShow cached sourceOpen source URL	"Financial Literacy Trainings" (FLT) for microcredit beneficiaries prepared by Swabhimaan, Inter Aide's partner in Pune (India)
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3. Study of uPA probes as a tool for diagnostic and biomarker application 4. Apoptosis imaging in colorectal cancer/18F-FLT as proliferation marker in neuroendocrine tumors 5. Study of predictive biomarkers for the use of anti-EGFR therapeutics (in head and neck squamous cell carcinoma)

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Onderzoekslijnen CORE - Oncologie 1. Studie van cellulaire en moleculaire interacties tussen chemotherapie, doelgerichte moleculaire therapie en radiotherapie, onder normoxische en hypoxische condities 2. Studie van de rol van MDM2 small molecule inhibitors in combinatie met klassieke chemo- en/of radiotherapie, onder normoxische en hypoxische condities 3. Studie van uPA probes voor diagnostisch en biomerkeronderzoek 4. Apoptose beeldvorming in colorectale kanker / 18F-FLT als proliferatiemerker in neuroendocriene tumoren 5. Studie van predictieve biomerkers voor anti-EGFR therapeutica (in hoofd-hals tumoren) 6. Prognostische en predictieve waarde van MET signalling en preklinische research op HGF- en MET-inhibitie als mono- en combinatietherapie bij de behandeling van longkanker 7. Ontrafeling van de CD70-CD27 biologie in verschillende tumortypes, met het oog op de ontwikkeling van biomerkers en nieuwe doelwitten 8. Studie van prognostische biomerkers in (colorectale) kanker ten behoeve van doelgerichte adjuvante therapie 9. Studie van de interactie tussen tumorcellen en macrofagen 10. Funcionele secretoomanalyse m.b.v. proteomics en viabiliteits- en motiliteits-assays bij pancreaskanker 11. Histomorfometrische en moleculair biologische studie van de motiliteit van carcinomacellen bij inflammatoire borstkanker 12. Studie naar resistentie van mTOR inhibitie bij pancreaskanker: analyse van de PI3K-Akt-mTOR pathway (samenwerking met Centrum Medische Genetica, UAntwerpen and Erasmus MC, Rotterdam) 13. Bepaling van het intra-tumorale genetische patroon bij colonkanker: moleculaire analyse van celvrij circulerend tumor-DNA (CtDNA) en circulerende tumorcellen (CTC) bij gemetastaseerde colonkanker (samenwerking met Centrum Medische Genetica, UAntwerpen) 14. Studie van DFNA5 als een potentiële biomarker en tumorsippressorgen bij verschillende tumortypes (samenwerking met Centrum Medische Genetica, UAntwerpen) 15. Stimulatie van de antitumor-immuniteit bij glioblastoom: evaluatie van hypoxie en Toll-like receptor gerelateerde therapeutica 16. Studie naar de therapeutische eigenschappen van Wilms tumor gen (WT1) mRNA-geëlectroporeerde autologe dendritische celvaccinaties bij patiënten met soliede tumoren (samenwerking met VAXINFECTIO) 17. Studie naar (WT1) mRNA-geëlectroporeerde autologe dendritische celvaccinaties in combinatie met adjuvante temozolomide chemotherapie bij blioblastoom (samenwerking met VAXINFECTIO)

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Select... 1 AD REGT LR SCOT PEMBROKE 1 CAD WINNIPEG//A1RES// 1 FD REGT HALIFAX 1 H LONDON 1 NS HIGHRS TRURO 1 R NFLD R ST JOHNS NFLD 1 RNBR FREDERICTON (Carleton & York) 1 WG HQ KINGSTON 10 EG QUEBEC 10 FD BTY 56 FD REGT ST CATHERINES 10 FD REGT REGINA 11 FD BTY, 11 FD REGT GUELPH 11 FD REGT GUELPH 11 MED COY VICTORIA 11 SVC BN VICTORIA 116 INDEP FD BTY KENORA 12 MED COY VANCOUVER 12 RBC TROIS-RIVIERES 12 SVC BN RICHMOND 12 WG HQ SHEARWATER//AR FLT// 13 FD BTY 26 FD REGT PORTAGE LA PRAIRIE 14 AES BRIDGEWATER//143 AEF// 14 AES BRIDGEWATER//CO// 14 SVC BN CALGARY 14 WG GREENWOOD//AR FLT// 15 FD REGT VANCOUVER 15 MED COY EDMONTON 15 MED COY EDMONTON 15 SVC BN EDMONTON 15 WG MOOSE JAW//AR FLT// 16 MED COY DET SASKATOON 16 MED COY REGINA 16 SASK SVC BN DET SASKATOON 16 SVC BN REGINA 16 WG BORDEN//AR FLT// 17 MED COY WINNIPEG 17 SVC BN WINNIPEG 17 WG WINNIPEG//AR FLT// 18 AD REGT LETHBRIDGE 18 MED COY THUNDER BAY 18 SVC BN THUNDER BAY 19 WG COMOX//AR FLT// 2 FD ENGR REGT TORONTO 2 FD REGT MONTREAL 2 INT COY WILLOWDALE 2 INT PL OTTAWA 2 IRISH R OF C SUDBURY 2 NS HIGHRS SYDNEY 2 R NFLD R CORNER BROOK 2 RNBR BATHURST 20 FD REGT EDMONTON 21 SVC BN WINDSOR ON 22 SVC BN LONDON 22 WG NORTH BAY//AR FLT// 23 MED COY HAMILTON 23 SVC BN HAMILTON 25 MED COY TORONTO 25 SVC BN TORONTO 26 FD REGT BRANDON 26 SVC BN OTTAWA 28 MED COY OTTAWA 28 SVC BN OTTAWA 3 ERE BAGOTVILLE//AR FLT// 3 FD REGT ST JOHN 3 FER WESTMOUNT 3 FES OTTAWA 3 INT COY HALIFAX 30 FD REGT OTTAWA 31 CBG HQ LONDON 31 CER ST THOMAS 31 SVC BN SAINT JOHN 32 CBG HQ TORONTO 33 CBG HQ OTTAWA 33 FD ENGR SQN CALGARY 33 MED PL HALIFAX 33 SVC BN HALIFAX 33 SVC BN HALIFAX//30 MP COY 35 MED COY SYDNEY 35 SVC BN SYDNEY 36 CBG HQ HALIFAX 36 NFLD SVC BN ST JOHNS NF 37 CBG HQ MONCTON 38 CBG HQ WINNIPEG 39 CBG HQ VANCOUVER 4 CIE RENS MONTREAL 4 R22ER LAVAL 4 RCR LONDON 4 WG COLD LAKE//AR FLT// 400 TAC HEL SQN BORDEN//CO// 402 SQN WINNIPEG//CO// 403 HEL OT SQN GAGETOWN//OIC AIR RES// 408 TAC HEL SQN EDMONTON//OC AR FLT// 41 CBG HQ CALGARY 427 TAC HEL SQN PETAWAWA//OC AR FLT// 430 ETAH VALCARTIER//OC ARF// 434 (CS) SQN GREENWOOD//SRC// 438 ETAH ST HUBERT//CO// 44 FD ENGR SQN TRAIL 440 (T) SQN YELLOWKNIFE//AR FLT COMD// 443 (MH) SQN ESQUIMALT 45 FES SYDNEY 48 HIGHRS TORONTO 49 FD REGT SAULT SAINT MARIE 5 BC FD REGT VICTORIA 5 WG GOOSE BAY//AR FLT// 51 MED COY MONTREAL 51 SVC BN RICHELAIN 52 MED COY SHERBROOKE 55 MED COY QUEBEC 55 PPM QUEBEC 55 SVC BN QUEBEC 56 FD ENGR SQN ST JOHNS NF 56 FD REGT BRANTFORD 57 FD BTY 6 FD REGT LEVIS

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Sélectionner... 1 AD REGT LR SCOT PEMBROKE 1 CAD WINNIPEG//A1RES// 1 FD REGT HALIFAX 1 H LONDON 1 NS HIGHRS TRURO 1 R NFLD R ST JOHNS NFLD 1 RNBR FREDERICTON (Carleton & York) 1 WG HQ KINGSTON 10 EG QUEBEC 10 FD BTY 56 FD REGT ST CATHERINES 10 FD REGT REGINA 11 FD BTY, 11 FD REGT GUELPH 11 FD REGT GUELPH 11 MED COY VICTORIA 11 SVC BN VICTORIA 116 INDEP FD BTY KENORA 12 MED COY VANCOUVER 12 RBC TROIS-RIVIERES 12 SVC BN RICHMOND 12 WG HQ SHEARWATER//AR FLT// 13 FD BTY 26 FD REGT PORTAGE LA PRAIRIE 14 AES BRIDGEWATER//143 AEF// 14 AES BRIDGEWATER//CO// 14 SVC BN CALGARY 14 WG GREENWOOD//AR FLT// 15 FD REGT VANCOUVER 15 MED COY EDMONTON 15 MED COY EDMONTON 15 SVC BN EDMONTON 15 WG MOOSE JAW//AR FLT// 16 MED COY DET SASKATOON 16 MED COY REGINA 16 SASK SVC BN DET SASKATOON 16 SVC BN REGINA 16 WG BORDEN//AR FLT// 17 MED COY WINNIPEG 17 SVC BN WINNIPEG 17 WG WINNIPEG//AR FLT// 18 AD REGT LETHBRIDGE 18 MED COY THUNDER BAY 18 SVC BN THUNDER BAY 19 WG COMOX//AR FLT// 2 FD ENGR REGT TORONTO 2 FD REGT MONTREAL 2 INT COY WILLOWDALE 2 INT PL OTTAWA 2 IRISH R OF C SUDBURY 2 NS HIGHRS SYDNEY 2 R NFLD R CORNER BROOK 2 RNBR BATHURST 20 FD REGT EDMONTON 21 SVC BN WINDSOR ON 22 SVC BN LONDON 22 WG NORTH BAY//AR FLT// 23 MED COY HAMILTON 23 SVC BN HAMILTON 25 MED COY TORONTO 25 SVC BN TORONTO 26 FD REGT BRANDON 26 SVC BN OTTAWA 28 MED COY OTTAWA 28 SVC BN OTTAWA 3 ERE BAGOTVILLE//AR FLT// 3 FD REGT ST JOHN 3 FER WESTMOUNT 3 FES OTTAWA 3 INT COY HALIFAX 30 FD REGT OTTAWA 31 CBG HQ LONDON 31 CER ST THOMAS 31 SVC BN SAINT JOHN 32 CBG HQ TORONTO 33 CBG HQ OTTAWA 33 FD ENGR SQN CALGARY 33 MED PL HALIFAX 33 SVC BN HALIFAX 33 SVC BN HALIFAX//30 MP COY 35 MED COY SYDNEY 35 SVC BN SYDNEY 36 CBG HQ HALIFAX 36 NFLD SVC BN ST JOHNS NF 37 CBG HQ MONCTON 38 CBG HQ WINNIPEG 39 CBG HQ VANCOUVER 4 CIE RENS MONTREAL 4 R22ER LAVAL 4 RCR LONDON 4 WG COLD LAKE//AR FLT// 400 TAC HEL SQN BORDEN//CO// 402 SQN WINNIPEG//CO// 403 HEL OT SQN GAGETOWN//OIC AIR RES// 408 TAC HEL SQN EDMONTON//OC AR FLT// 41 CBG HQ CALGARY 427 TAC HEL SQN PETAWAWA//OC AR FLT// 430 ETAH VALCARTIER//OC ARF// 434 (CS) SQN GREENWOOD//SRC// 438 ETAH ST HUBERT//CO// 44 FD ENGR SQN TRAIL 440 (T) SQN YELLOWKNIFE//AR FLT COMD// 443 (MH) SQN ESQUIMALT 45 FES SYDNEY 48 HIGHRS TORONTO 49 FD REGT SAULT SAINT MARIE 5 BC FD REGT VICTORIA 5 WG GOOSE BAY//AR FLT// 51 MED COY MONTREAL 51 SVC BN RICHELAIN 52 MED COY SHERBROOKE 55 MED COY QUEBEC 55 PPM QUEBEC 55 SVC BN QUEBEC 56 FD ENGR SQN ST JOHNS NF 56 FD REGT BRANTFORD 57 FD BTY 6 FD REGT

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