ddc – Übersetzung – Keybot-Wörterbuch

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ddC (Hivid);
ddC (Hivid)
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analogues nucléosidiques – AZT (zidovudine, Retrovir), d4T (stavudine, Zerit), ddI (didanosine, Videx), ddC, 3TC (lamivudine), abacavir (Ziagen) et ténofovir (Viread)
nukes – AZT (zidovudine, Retrovir), d4T (stavudine, Zerit), ddI (didanosine, Videx), ddC, 3TC (lamivudine), abacavir (Ziagen) and tenofovir (Viread)
  La neuropathie périphér...  
L’acétyl-carnitine est un acide aminé dont peuvent manquer les personnes chez qui la NP est secondaire à un traitement par ddl, ddC ou d4T. La prise d’un supplément d’acétyl-carnitine peut se révéler utile pour prévenir ou traiter la neuropathie périphérique.
Acetyl-carnitine is an amino acid that may be deficient in people who develop PN while using ddI, ddC or d4T. Taking a supplement of acetyl-carnitine may be useful to prevent or treat PN.
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Dans un premier temps, ces trois médicaments que l'on surnommait couramment les médicaments « d » semblaient être mieux tolérés, mais leurs effets secondaires n'ont pas tardé à se manifester, notamment la neuropathie périphérique (nerfs douloureux dans les mains, les pieds et les jambes). On ne fabrique plus le ddC, et les lignes directrices des pays à revenu élevé découragent maintenant l'usage du d4T et du ddI.
These three drugs, commonly called d-drugs, initially appeared to be better tolerated but soon showed their own side effects, such as peripheral neuropathy (painful nerves in the hands, feet and legs). ddC is no longer manufactured and treatment guidelines in high-income countries now discourage the use of d4T and ddI.
  La vitamine B12 | CATI...  
Les symptômes d’une neuropathie périphérique consistent en picotements ou brûlures dans les mains et les pieds. On associe souvent cette affection aux médicaments anti-VIH, plus particulièrement au ddC, au ddI et au d4T.
Peripheral neuropathy is a tingling or burning in the hands and feet. It is often associated with anti-HIV drugs, particularly ddC, ddI and d4T. One early study suggested that people with HIV who have low B12 levels were more likely to experience neuropathy, but subsequent studies have not confirmed this connection. B12 has, however, been used successfully to treat diabetic neuropathy, a fact that argues its case for the management of nerve damage in people with HIV.
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Le terme acidose lactique désigne une affection caractérisée par l’accumulation d’acide lactique dans le sang. Il s’agit d’un effet secondaire rare qui pourrait être attribuable à l’usage d’analogues nucléosidiques anti-VIH tels que l’AZT, le ddI, le ddC, le d4T et le 3TC.
Lactic acidosis is the name given to a condition where high levels of lactic acid build up in the blood. It is a rare side effect that may be associated with the use of nukes used to treat HIV, such as AZT, ddI, ddC, d4T and 3TC. It may also occur in people with HIV who use the nuke ribavirin, particularly if they also use the nukes ddI (didanosine, Videx, Videx EC) and/or d4T (stavudine, Zerit). These drugs damage the energy-producing parts, or power plant, of a cell. When a cell can't produce enough power, it begins to malfunction and can die. The following signs/symptoms can develop when a person has lactic acidosis:
  La neuropathie périphér...  
La neuropathie périphérique peut également être un effet secondaire de certains médicaments, particulièrement les antirétroviraux tels que le ddI, le d4T et le ddC, ainsi que d’autres médicaments utilisés dans le traitement des affections liées au VIH comme la thalidomide, Flagyl (métronidazole), la dapsone, l’isoniazide et les médicaments anticancéreux telle la vincristine.
Peripheral neuropathy (PN) is a form of nerve damage usually felt as numbness, tingling, burning, or pain in the toes and feet, and sometimes in the fingers and hands. People with HIV can experience PN either because of the direct effects of HIV on the nervous system, at any stage of infection, or because of other infections and tumours that affect the nervous system. PN can also be a side effect of some drugs, especially the antiretrovirals ddI, d4T and ddC, as well other drugs used to treat HIV-related conditions, including thalidomide, Flagyl (metronidazole), dapsone, isoniazid, and anticancer drugs like vincristine. Recreational drugs such as alcohol, cocaine or amphetamines may contribute to PN.
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Les médicaments anti-VIH AZT, 3TC, ddI, ddC, abacavir et d4T sont des inhibiteurs nucléosidiques de la transcriptase inverse. Ils contribuent à ralentir la production de VIH en interférant avec une des enzymes du virus appelée transcriptase inverse.
The anti-HIV drugs AZT, 3TC, ddI, ddC, abacavir and d4T are called nucleoside reverse transcriptase inhibitors (NRTI). They help to slow down HIV reproduction by interfering with one of the virus’s enzymes called reverse transcriptase. Over time, these drugs may damage the mitochondria inside a PHA’s cells. Mitochondria are the energy producing centres of a cell. Several B vitamins play a role in the processing of energy in mitochondria. Given this connection, it is possible that the combination of B vitamin deficiency and the use of NRTIs leads to mitochondrial dysfunction and damage.
  L’huile d’onagre | CATI...  
La neuropathie périphérique (NP) provoque une sensation de picotement ou de brûlure dans les mains et les pieds. Elle est souvent associée aux médicaments anti-VIH ddI, ddC et d4T. La neuropathie périphérique se manifeste également chez les personnes atteintes de diabète.
Peripheral neuropathy (PN) is a burning or tingling in the hands and feet. It is associated with the use of the anti-HIV drugs ddI, d4T and ddC. PN also occurs in people with diabetes. Several trials have shown that evening primrose oil can help relieve the symptoms of diabetic PN. In one study, 22 people who took four grams of evening primrose oil daily for six months had a significant improvement in symptoms. Evening primrose oil appears to be more effective for this purpose than other oils containing GLA such as borage or black currant oil. Evening primrose oil has not been studied as a treatment for peripheral neuropathy in people with HIV. Nevertheless, nutritionists like Lark Lands recommend GLA supplements in combination with B-complex vitamins, vitamin E and omega-3 fatty acid supplements for PHAs suffering from neuropathy.