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It is important to note that in laboratory animals, the developmental neurotoxic effects of lead have been shown to persist after exposures have ceased, and blood and brain lead levels have returned to normal or control levels (Rice and Barone 2000). In humans, the developmental neurotoxic effects of lead have been shown to persist until the late teenage years. Lead has been shown to interact with multiple cell types in the central nervous system, and potential modes of action supported by experimental evidence have been developed to explain the observed developmental neurotoxicity of lead. These modes of action are considered relevant to humans.
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