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5. Armstrong, J. P. K., Shakur, R., Horne, J. P., Dickinson, S. C., Armstrong, C. T., Lau, K., Kadiwala, J., Lowe, R., Seddon, A., Mann, S., Anderson, J. L. R., *Perriman, A. W., *Hollander, A. P., Artificial membrane binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue.
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These findings challenge the existing dogma that describes the role of water molecules in determining protein structure and function, and the robustness of this facile approach for achieving protein fluidity indicates that it could readily be developed for a wide range of biomolecules. Moreover, the development of the methodologies surrounding these novel hybrid constructs will not only provide insights into the role of water in protein folding, dynamics and function, but will also provide a gateway to the development of new technologies that will impact on industrial biocatalysis4 and regenerative medicine5.
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