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www.areva.com
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Ces déchets relèvent de plusieurs catégories définies par le législateur
et conduisant à
la prise en compte de dispositions particulières : déchets industriels (dangereux ou non) et radioactifs.
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areva.com
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This waste falls into various categories defined by law, with specific provisions that must be taken into account: (hazardous and non-hazardous) industrial waste and radioactive waste.
www.pc.gc.ca
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La dépression avait servi de catalyseur pour ces réformes fondamentales, révélant l'insécurité économique de la société moderne
et conduisant à
une expansion des activités du gouvernement fédéral dans le domaine des principaux services d'aide sociale.
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pc.gc.ca
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The Unemployment Insurance Act and the Family Allowances Act were notable pieces of social legislation and set Canada firmly on the path to a social welfare state. They would be followed over the years by many others: for example, the Old Age Security Act of 1951, the Canada Pension Plan of 1964, the Canada Health Act, a comprehensive national health insurance program (or medicare, as it was popularly known) in 1966. The Great Depression had served as the catalyst for these fundamental reforms, revealing the economic insecurity of modern society and leading to the expansion of federal government activity in assuming responsibility for major social welfare services.
team.inria.fr
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L’équipe-projet E-MOTION a pour ambition de développer des modèles et des méthodes algorithmiques permettant à terme de construire des systèmes artificiels dotées de capacités de perception, de décision, et d’action suffisamment évoluées et robustes pour autoriser un fonctionnement de ceux-ci dans des environnements ouverts (i.e. partiellement connus), à forte dynamicité (i.e. où le temps et la dynamique jouent un rôle essentiel),
et conduisant à
des interactions variées avec l’homme.
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team.inria.fr
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The project-team E-MOTION aims at developing algorithmic models and methods allowing to build artificial systems equipped with capacities of perception, decision, and action sufficiently advanced and robust to allow them to operate in open and dynamic environments (i.e. in partially known environments, where time and dynamics play a major role), and leading to varied interactions with human. Recent tehnological progresses on embedded computational power, on sensors technology, and on miniaturized mechatronic systems, make the required technological breakthroughs potentially possible (including from the scalability point of view). In order to try to reach this objective, we propose to combine the respective benefits of computational geometry, of probability theory and in certain cases of the biological inspiration (by working in cooperation with some neurophysiologists).
actu.epfl.ch
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On connaissait déjà l’hypophosphatase, une maladie humaine due à l’absence de ce gène
et conduisant à
une extrême fragilité du squelette, dès le plus jeune âge. «Cette nouvelle découverte nous permet de conclure qu’un défaut d’expression du gène de la phosphatase alcaline finit par avoir des effets sur la solidité des os à l’âge mûr. Or les fractures sont la première cause d’hospitalisation des personnes âgées», précise Johan Auwerx, directeur du LISP.
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actu.epfl.ch
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Scientists were already familiar with hypophosphatase, a human disease caused by the absence of this gene that leads to extreme skeletal fragility from a very young age. “With this new discovery we can conclude that a defect in the gene expression for alkaline phosphatase affects bone strength in mature adults. In fact, fractures are the primary cause for hospitalization in the elderly,” says LISP director Johan Auwerx. Pénélope Andreux, a co-author of the study, adds that the gene has other jobs in the cell as well: “it plays an important role in vitamin B6 absorption, which is involved in protein metabolism,” she explains.
www.marsh.com
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La gestion des risques liés à la responsabilité civile relative à un produit
et conduisant à
une exposition des administrateurs et dirigeants (A&D) peut représenter un défi pour les organisations mondiales.
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marsh.com
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Managing product liability risks resulting in directors and officers (D&O) exposures can be challenging for global organizations. The chain of events leading to a D&O claim — from initial product development and subsequent recall to how the organization responds to whistleblowers and investigations — can result in immediate revenue and reputational losses.
www.buddhismuskunde.uni-hamburg.de
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Enrichies de bourgs médiévaux, de forteresses, châteaux, villas patriciennes et musées, les Collines Euganei sont en outre l’objectif idéal des amateurs de nature, de vélo, d’excursions, mais aussi d’art et d’histoire. Des itinéraires d'excursions partent en effet de toutes les localités, présentant différents niveaux de difficulté
et conduisant à
la découverte de lieux riches et envoûtants.
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atlanticterme.com
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Enhanced by medieval villages, fortresses, castles, Patrician villas and museums, the Euganean hills are the ideal destination for people who are nature-oriented, love cycling and hiking, but also love art and history. Hiking tours of varying levels of difficulty depart from every town and open up to extraordinary vistas.
www.roundshot.com
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La région de Kapetaniana et Asterousia est parsemée de chemins menant à des grottes, des monastères, des ermitages et des criques désertes, traversant des ravins
et conduisant à
des endroits bien cachés et d'une beauté extraordinaire.
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thalori.com
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Hiking is the best way for someone to discover an unknown place and the area of Kapetaniana and Asterousia is full of scattered trails leading to caves, monasteries, hermitages and secluded bights, trails which cross canyons and lead to unseen places of extraordinary beauty. The ascent to Kofinas and the trail that connects Agios Ioannis and the monastery of Koudoumas is just the beginning. We recommend a total of 10 marked trails for beginners and experienced hikers.
arkisto.fi
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Parmi ses projets récents se trouvent ceux-ci : atelier d'encadrement de marque; Digital Marketing Solutions : approche de mentor pour la planification stratégique du comté de Dorion; rédaction réussie d'une proposition de service d'encadrement pour la bande indienne de Red Rock; atelier d'encadrement pour le leadership communautaire, à la demande de la Greenstone Economic Development Corporation; encadrement lors d'une séance de perfectionnement du conseil d'administration; formation pour l'accompagnement de cadres
et conduisant à
une désignation professionnelle.
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nswpb.ca
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Putting vision into practice, sharing creative ideas and empowering people through organizational activities is why Dave is ready to help lead the charge to make good things happen. Recent projects include: a Brand Coaching Workshop: Digital Marketing Solutions, a Coach Approach to strategic planning for the Township of Dorion; a Coaching Proposal Writing Success for the Red Rock Indian Band; Community Leadership Coach Workshop for the Greenstone Economic Development Corporation; Coaching Board of Directors' Development Session for the Superior North Community Development Corporation and Executive Coach Training that can lead to a professional designation. His strategic planning skills are evident in the organizations and companies he helps stretch well beyond their perceived potential. Executive coaching sessions for individuals is ongoing and he coaches management teams individually and as a group for success. As a catalyst for exceptional outcomes, he has built a solid reputation for success, which included being a member of the Canadian delegation to NAFTA for being a leader in implementing environmental management system.
www.hisice-carna.eu
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La myopathie de Duchenne (DMD) est une maladie génétique qui touche 1 garçon sur 5000 naissances, aujourd’hui sans traitement efficace
et conduisant à
la perte d’autonomie à l’adolescence au decès des patients jeunes adultes.
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imrb.inserm.fr
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Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease, affecting 1 in 5000 live male births and is characterized by a progressive degeneration of myofibres, leading to an irreversible muscle weakness. In DMD, as in many muscle wasting conditions, cell death mechanisms are largely unknown. Within the team 10 directed by Frederic Relaix and Jérôme […]
www.conventions.coe.int
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5 Les Parties coopèrent dans la mesure la plus large possible en conformité avec leur droit interne avec les Parties qui sollicitent l’exécution de mesures équivalentes à la confiscation
et conduisant à
une privation de propriété, qui ne constituent pas des sanctions pénales, dès lors que de telles mesures ont été ordonnées par une autorité judiciaire de la Partie requérante sur la base d’une infraction pénale et dans la mesure où il est établi que les biens constituent des produits ou des biens visés à l’article 5 de cette Convention.
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conventions.coe.int
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5,The Parties shall co-operate to the widest extent possible under their domestic law with those Parties which request the execution of measures equivalent to confiscation leading to the deprivation of property, which are not criminal sanctions, in so far as such measures are ordered by a judicial authority of the requesting Party in relation to a criminal offence, provided that it has been established that the property constitutes proceeds or other property in the meaning of Article 5 of this Convention.
www.chi-residences.com
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La démence (trouble cognitif retentissant sur la vie du sujet
et conduisant à
une perte d’autonomie) est observée chez 20% des patients âgés de plus de 55 ans. Elle est fréquemment associée à d’autres signes de gravité de la maladie : troubles de la marche, incontinence urinaire et parfois à un syndrome pseudo-bulbaire (troubles de la déglutition, rire ou pleurer spasmodiques).
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cervco.fr
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Mood disturbance are observed in one in five patients. They may be early (up to 10% of patients), sometimes inuagural and lead to an error or delay in diagnosis. Some patients describe symptoms of severe depression suggesting melancholia, alternating, in a few cases, with episodes of mania (this can lead to the presumptive diagnosis of bipolar disorder). Apathy (loss of motivation) is a frequent sign of the disease, depending on the location of the brain lesions. It is not always secondary to depression.
www.ganischger.com
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L’Inmed est un lieu de vie où le partage de moyens, savoir-faire, ressources et équipements, facilite l’émergence des collaborations et des échanges renforçant ainsi la cohérence thématique de l’Institut et facilitant des approches multidisciplinaires
et conduisant à
de nombreuses découvertes.
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inmed.fr
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INMED is a living place where sharing expertise, resources and equipment, facilitates the emergence of collaborations and exchanges between our independent teams, strengthening the thematic coherence of the Institute and facilitating multidisciplinary approaches leading to several important discoveries.
www.agro.eu
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Lorsqu'il est utilisé pour son bon modèle de froide interne de longue date survenant dans un contexte de déficit
et conduisant à
la stase du sang, cette formule est très efficace. Un signe essentiel pour son l'utilisation est que la couleur la langue soit pâle ou bleu violacé.
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eqilibrium.net
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When used for its proper pattern of long-standing internal Cold occurring against a background of Deficiency and leading to stasis of Blood, this formula is very effective. An essential sign for its use is that the tongue-body colour be Pale or Bluish-Purple.
www.anmeldestelle.admin.ch
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les substances dangereuses dans les préparations
et conduisant à
la classification comme dangereuses de celles-ci (substances contenues en dessus des limites de concentration selon CLP ou la directive sur les préparations dangereuses 1999/45 CE)
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anmeldestelle.admin.ch
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hazardous substances in preparations that lead to the classification as hazardous (above concentration limits specified in CLP or comprising preparations-DPD 1999/45 EC)
www.finances.gouv.qc.ca
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1998 : Réforme comptable élargissant le périmètre comptable du gouvernement
et conduisant à
la création de Financement-Québec.
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finances.gouv.qc.ca
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1998: Accounting reform broadening the reporting entity of the government and resulting in the creation of Financement-Québec
conventions.coe.int
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5 Les Parties coopèrent dans la mesure la plus large possible en conformité avec leur droit interne avec les Parties qui sollicitent l’exécution de mesures équivalentes à la confiscation
et conduisant à
une privation de propriété, qui ne constituent pas des sanctions pénales, dès lors que de telles mesures ont été ordonnées par une autorité judiciaire de la Partie requérante sur la base d’une infraction pénale et dans la mesure où il est établi que les biens constituent des produits ou des biens visés à l’article 5 de cette Convention.
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conventions.coe.int
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5,The Parties shall co-operate to the widest extent possible under their domestic law with those Parties which request the execution of measures equivalent to confiscation leading to the deprivation of property, which are not criminal sanctions, in so far as such measures are ordered by a judicial authority of the requesting Party in relation to a criminal offence, provided that it has been established that the property constitutes proceeds or other property in the meaning of Article 5 of this Convention.
www-ibmc.u-strasbg.fr
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Dans le cadre d’une étude comparative, nous avons traité un modèle de carcinome humain du poumon in vivo avec des séquences de siRNA, induisant de la cytotoxicité
et conduisant à
la mort cellulaire, en utilisant des liposomes cationiques ou des MWNT fonctionnalisés avec des groupes ammonium (Podesta, J.E. et al. Small 2009, 5, 1176).
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www-ibmc.u-strasbg.fr
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Carbon nanotubes functionalized with ammonium groups are able to form supramolecular complexes with nucleic acids and in particular with plasmid DNA and oligodeoxynucleotides containing the CpG motifs (Lacerda, L. et al. J. Mater. Chem. 2008, 18, 17). Following this work, we are expanding the delivery capacity of positively charged CNTs to siRNA sequences (Fig. 3). In a comparative study, we have treated a human lung carcinoma model in vivo using siRNA sequences leading to cytotoxicity and cell death using either cationic liposomes or ammonium-functionalized MWNTs (f-MWNTs) (Podesta, J.E. et al. Small 2009, 5, 1176). We have found that the selected cytotoxic siRNA sequence led to significant cytotoxic activities delivered both by liposome or f-MWNTs in vitro. Using both types of vector only cationic MWNT:siRNA complexes administered intratumorally delayed tumor growth and increased survival of xenograft-bearing animals. The direct comparison between carbon nanotubes and liposomes demonstrates the potential advantages offered by CNTs for the intracellular delivery of siRNA-based therapeutic agents in vivo. We have further developed alternative f-CNTs for siRNA delivery. A new series of polycationic dendron-MWNT constructs with a precisely tailored number of amino functions can complex and effectively deliver double-stranded siRNA to achieve gene silencing in vitro. The positive charges on the MWNT surface, coupled with the unique ability of CNTs to penetrate cell membranes, make the new derivatives potentially ideal vectors for siRNA delivery (Singh, P. et al. J. Mater. Chem. 2011, 21, 4850).