induire une réponse immunitaire – English Translation – Keybot Dictionary

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  www.listeriosis-listeriose.investigation-enquete.gc.ca  
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Substance capable d'induire une réponse immunitaire.
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A substance capable of inducing an immune response.
  www.agr.ca  
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Substance capable d'induire une réponse immunitaire.
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A substance capable of inducing an immune response.
  www.primum1.com  
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L'administration de protéines recombinantes ou de substances biologiques chez l'humain peuvent induire une réponse immunitaire conduisant à la production d'anticorps ce qui, dans certains cas, peut neutraliser leur activité.
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  ccac.ca  
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Si cette voie d'injection de l'ACF doit être utilisée, il faut qu'elle soit justifiée d'une façon scientifique irréfutable parce qu'elle est responsable du développement d'ulcérations et d'infections fréquentes aux sites d'injection. L'utilisation de la voie intradermique peut être justifiée uniquement lorsque l'objectif visé est d'induire une réponse immunitaire d'origine cellulaire.
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Sound scientific evidence and justification must be available if the intradermal route of injection of FCA is to be used, because of the frequent ulceration and infections that occur at the site of such injections. The use of the intradermal route may be justified only when the purpose is to induce cell-mediated response.
  www.ccac.ca  
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Si cette voie d'injection de l'ACF doit être utilisée, il faut qu'elle soit justifiée d'une façon scientifique irréfutable parce qu'elle est responsable du développement d'ulcérations et d'infections fréquentes aux sites d'injection. L'utilisation de la voie intradermique peut être justifiée uniquement lorsque l'objectif visé est d'induire une réponse immunitaire d'origine cellulaire.
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Sound scientific evidence and justification must be available if the intradermal route of injection of FCA is to be used, because of the frequent ulceration and infections that occur at the site of such injections. The use of the intradermal route may be justified only when the purpose is to induce cell-mediated response.
  www.hc-sc.gc.ca  
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Certains vaccins sont composés de microorganismes vivants, atténués juste ce qu'il faut pour ne pas communiquer une maladie, mais capables, néanmoins, d'induire une réponse immunitaire chez la personne vaccinée.
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Vaccines differ from chemical drugs because of the biological nature of the source materials (such as those derived from microorganisms and viruses), the biological methods used to test them and because they are highly complex substances. Some vaccines consist of live microorganisms suitably changed to ensure that they no longer produce disease but can still produce a suitable immune response. Special expertise and procedures are needed for their manufacture, control, and regulation. Vaccines are also unique in that they are often recommended as part of Canadian public health programs, which means they are administered to very large numbers of healthy people, including infants and children; thus safety and quality are paramount.
  hc-sc.gc.ca  
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Certains vaccins sont composés de microorganismes vivants, atténués juste ce qu'il faut pour ne pas communiquer une maladie, mais capables, néanmoins, d'induire une réponse immunitaire chez la personne vaccinée.
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Vaccines differ from chemical drugs because of the biological nature of the source materials (such as those derived from microorganisms and viruses), the biological methods used to test them and because they are highly complex substances. Some vaccines consist of live microorganisms suitably changed to ensure that they no longer produce disease but can still produce a suitable immune response. Special expertise and procedures are needed for their manufacture, control, and regulation. Vaccines are also unique in that they are often recommended as part of Canadian public health programs, which means they are administered to very large numbers of healthy people, including infants and children; thus safety and quality are paramount.
  www.nrc-cnrc.gc.ca  
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L'un des inconvénients majeurs de ces systèmes est la nécessité de recourir, d'une part, à une étape de repliement protéique qui confère à l'IFN-a2b recombinant une structure tridimensionnelle la rendant active et, d'autre part, à une étape de couplage au PEG pour atténuer les conséquences négatives associées à la forme non glycosylée de la protéine. Non seulement ces processus additionnels diminuent le rendement (généralement < 20 %), mais ils peuvent également réduire l'activité spécifique et induire une réponse immunitaire.
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The antiviral, antiproliferative, and immunomodulatory activities exhibited by interferons have led to their use as therapeutic agents. Interferon alpha-2b (IFN-α2b) is the predominant subvariant of interferons. Some of the many diseases treated with IFN-α2b, alone or in combination, include type B and C hepatitis, and several cancers. Human recombinant IFN-α2b used in the clinic is currently synthesized in bacterial systems. A major inconvenient of these systems is the requirement for a refolding step to restore recombinant IFN-α2b to its correct and active 3-D structure and a peggylation step to alleviate the negative impacts associated with a non-glycosylated form of the protein. These extra processes not only reduce recovery rates (typically <20%), but they may lower specific activity and may trigger an immune response. To circumvent the barriers of bacterial expression systems, a mammalian HEK293 cell line constitutively expressing the EBNA1 protein of EBV (clone 6E) was used in combination with a plasmid derivative of the pTT vector encoding the human IFN-α2b gene to generate IFN-producing clones (NRC no. 11565 & 11266). One clone that stably produced high IFN-α2b levels while maintaining a high growth rate was selected. This clone was shown to produce biologically active IFN-α2b with a gene reporter assay. Further, a purification process allowing high purity and recovery was also developed. Together, these results demonstrate the ability to cost-effectively produce and purify potent glycosylated IFN-α2b from human cells.