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  Chercheurs – MIREC Canada  
3) Exposition aux formes libre et conjuguée du bisphénol A (BPA) et du triclosane (TCS) durant la grossesse au sein de la cohorte MIREC
3) Exposure to free and conjugated forms of Bisphenol A (BPA) and Triclosan (TCS) during Pregnancy within the MIREC Study
  Exposition prénatale au...  
Cette étude ne montre aucune association entre les taux urinaires de phtalates et de BPA ou les taux sériques de SPFA de la mère et les concentrations sériques d’IL-33, de TSLP et d’IgE dans le cordon ombilical.
This study found that neither phthalates nor BPA in maternal urine nor PFASs in maternal blood were associated with elevated levels of either IL-33, TSLP or IgE in umbilical cord blood.
  Exposition des femmes a...  
Au total, 2001 participantes de l’étude MIREC ont été évaluées à leur 1er trimestre de grossesse; les chercheurs ont détecté du BPA chez 1742 d’entre elles, du triclosan, chez 1699, et des phtalates chez 1597.
A total of 2,001 women from the MIREC Study were assessed during their first trimester of pregnancy, with 1,742 women included in the BPA analysis, 1,699 in the triclosan analysis, and 1,597 in the phthalates analysis.
  Exposition aux phtalate...  
Les résultats indiquent que l’exposition aux BPA et aux phtalates chez les participantes de MIREC était comparable ou inférieure à celle observée chez les femmes en âge de procréer ayant participé à l’Enquête canadienne sur les mesures de la santé (ECMS).
This research provides the first biomonitoring results for the largest population of pregnant women sampled in the first trimester. The results show that exposure to BPA and phthalates among MIREC women is comparable to or even lower than that seen in women of reproductive age who participated in the Canadian Health Measures Survey (CHMS), a national population-based survey.
  Étude des liens entre l...  
Les échantillons d’urine, fournis par les participantes au 1er trimestre de grossesse, ont servi à mesurer le BPA et 11 métabolites de phtalates. Des produits chimiques comme les phtalates peuvent être absorbés par le corps, puis décomposés (métabolisés) et excrétés dans l’urine sous forme de métabolites.
Urine samples were collected from the pregnant women in their first trimester and analyzed for BPA and 11 phthalate metabolites. Chemicals such as phthalates can be absorbed into the body, then broken down (metabolized) and excreted in urine as metabolites. The researchers then assessed the relationship between phthalate and BPA levels in mother’s urine and levels of adiponectin and leptin in umbilical cord blood.
  Mesure par GC-MS du bis...  
Pour mieux étudier le BPA présent dans le lait maternel, des chercheurs de Santé Canada ont mis au point une nouvelle méthode d’analyse de laboratoire très précise, qu’ils ont utilisée pour analyser 278 échantillons de lait provenant des participantes de l’étude MIREC.
Furthermore, the levels of free and total BPA in most of the human milk samples were low, and they were also lower than those reported in other countries. As well, based on the low rate of detection of the more active form of BPA (“free” BPA) in the samples, the researchers stated that, “in general, dietary exposure to BPA for Canadian breast-fed infants is expected to be somewhat lower compared with exposure among formula-fed infants.”
  Mesure par GC-MS du bis...  
Les Canadiens sont de plus en plus sensibilisés à la présence de bisphénol A (BPA) dans leur environnement, notamment dans des produits d’usage courant. Par exemple, le BPA sert à la fabrication des plastiques durs et transparents.
To have a better understanding of the levels of BPA in mothers’ breast milk, researchers at Health Canada developed and used a novel and precise laboratory method to analyze 278 milk samples collected from the MIREC Study participants. Total BPA was found in only 26% of the samples, while the more biologically active form of BPA, known as “free BPA”, was detected in 16.5% of the milk samples.
  Mesure par GC-MS du bis...  
Pour mieux étudier le BPA présent dans le lait maternel, des chercheurs de Santé Canada ont mis au point une nouvelle méthode d’analyse de laboratoire très précise, qu’ils ont utilisée pour analyser 278 échantillons de lait provenant des participantes de l’étude MIREC.
Furthermore, the levels of free and total BPA in most of the human milk samples were low, and they were also lower than those reported in other countries. As well, based on the low rate of detection of the more active form of BPA (“free” BPA) in the samples, the researchers stated that, “in general, dietary exposure to BPA for Canadian breast-fed infants is expected to be somewhat lower compared with exposure among formula-fed infants.”
  Exposition prénatale au...  
Dans la présente étude, des chercheurs de l’université Dalhousie se sont penchés sur les liens entre l’exposition prénatale aux phtalates, au BPA et aux SPFA et les concentrations d’IgE, de TSLP et d’IL-33 dans le sang de cordon ombilical.
Although previous studies have looked at the role of IgE, TSLP, and IL-33 in the development of childhood allergic diseases, these biomarkers have not been adequately studied during the crucial period of fetal immune system development. In this study, researchers at Dalhousie University looked at the relationship between prenatal exposure to phthalates, BPA, and PFASs, and levels of IgE, TSLP, and IL-33 in umbilical cord blood. The researchers analyzed data collected in the MIREC Study. Of the 2,001 pregnant women in the MIREC cohort, 1,258 had a singleton, term birth and cord blood sample. The analysis was adjusted for other environmental contaminants correlated with those of interest and which could potentially influence the study results.
  Exposition aux phtalate...  
Les phtalates et le BPA sont tous deux des perturbateurs hormonaux (ou « endocriniens ») possiblement liés à des effets nocifs sur la reproduction et le neurodéveloppement. On les retrouve couramment dans les échantillons d’urine, lors d’enquêtes sur les populations, mais peu de données existaient sur les femmes enceintes en particulier, notamment au 1er trimestre de la grossesse, période critique pour le développement de l’enfant.
Phthalates and BPA are both hormone (or “endocrine”) disruptors possibly linked to harmful reproductive and neurodevelopmental effects. These chemicals have commonly been measured in urine collected in population surveys, but less is known about their levels in populations of pregnant women, especially for the critical first trimester of pregnancy. For this reason, research was carried out to measure BPA and phthalate metabolites in first trimester urine samples collected from pregnant women participating in the MIREC Study, and to identify factors that predict exposure to these two environmental chemicals. (Metabolites are substances produced during metabolism, or bodily chemical processes, and may also refer to products that remain after a substance is broken down, or metabolized, by the body). A questionnaire was used to gather demographic and socio-economic information on the roughly 2,001 women who were recruited during the first trimester of pregnancy from ten cities across Canada, and a one-time urine sample was collected and analyzed for total BPA and 11 phthalate metabolites.
  Exposition aux phtalate...  
Les phtalates et le BPA sont tous deux des perturbateurs hormonaux (ou « endocriniens ») possiblement liés à des effets nocifs sur la reproduction et le neurodéveloppement. On les retrouve couramment dans les échantillons d’urine, lors d’enquêtes sur les populations, mais peu de données existaient sur les femmes enceintes en particulier, notamment au 1er trimestre de la grossesse, période critique pour le développement de l’enfant.
Phthalates and BPA are both hormone (or “endocrine”) disruptors possibly linked to harmful reproductive and neurodevelopmental effects. These chemicals have commonly been measured in urine collected in population surveys, but less is known about their levels in populations of pregnant women, especially for the critical first trimester of pregnancy. For this reason, research was carried out to measure BPA and phthalate metabolites in first trimester urine samples collected from pregnant women participating in the MIREC Study, and to identify factors that predict exposure to these two environmental chemicals. (Metabolites are substances produced during metabolism, or bodily chemical processes, and may also refer to products that remain after a substance is broken down, or metabolized, by the body). A questionnaire was used to gather demographic and socio-economic information on the roughly 2,001 women who were recruited during the first trimester of pregnancy from ten cities across Canada, and a one-time urine sample was collected and analyzed for total BPA and 11 phthalate metabolites.
  Exposition aux phtalate...  
Les phtalates et le BPA sont tous deux des perturbateurs hormonaux (ou « endocriniens ») possiblement liés à des effets nocifs sur la reproduction et le neurodéveloppement. On les retrouve couramment dans les échantillons d’urine, lors d’enquêtes sur les populations, mais peu de données existaient sur les femmes enceintes en particulier, notamment au 1er trimestre de la grossesse, période critique pour le développement de l’enfant.
Phthalates and BPA are both hormone (or “endocrine”) disruptors possibly linked to harmful reproductive and neurodevelopmental effects. These chemicals have commonly been measured in urine collected in population surveys, but less is known about their levels in populations of pregnant women, especially for the critical first trimester of pregnancy. For this reason, research was carried out to measure BPA and phthalate metabolites in first trimester urine samples collected from pregnant women participating in the MIREC Study, and to identify factors that predict exposure to these two environmental chemicals. (Metabolites are substances produced during metabolism, or bodily chemical processes, and may also refer to products that remain after a substance is broken down, or metabolized, by the body). A questionnaire was used to gather demographic and socio-economic information on the roughly 2,001 women who were recruited during the first trimester of pregnancy from ten cities across Canada, and a one-time urine sample was collected and analyzed for total BPA and 11 phthalate metabolites.
  Étude des liens entre l...  
Or, certains contaminants environnementaux comme le bisphénol A (BPA) et les phtalates peuvent perturber l’action de ces hormones, d’où leur appellation de « perturbateurs hormonaux (ou endocriniens) ».
Metabolic dysfunction is a term used to describe an impairment in how the body uses and stores energy and can be associated with higher rates of obesity and diabetes. Obesity and type-2 diabetes have been steadily rising in the Canadian population (and in other countries as well), and it is suspected that prenatal exposure to environmental contaminants is a contributing factor. These two diseases are metabolic in nature, affecting both fat metabolism and carbohydrate (sugar) metabolism. A feature common to both these metabolic processes is the involvement of specific hormones. Certain environmental contaminants, such as bisphenol A (BPA) and phthalates, can potentially disrupt these hormones and are thus referred to as “hormone (or endocrine) disruptors”. BPA is used to make a hard, clear plastic and may also be found in epoxy resin linings on the inside of metal-based food and beverage cans. Thermal papers such as receipts and tickets may also be a source of BPA. Phthalates are a family of chemicals commonly used to make plastics soft and flexible and harder to break. They are often called plasticizers and have a large number of industrial and commercial uses – for example, vinyl flooring, adhesives, detergents, automotive plastics, some children’s toys, and personal-care products (soaps, shampoos, hair spray, nail polishes). Some phthalates are also used as solvents for other materials. Given the widespread use of BPA and phthalates, the Canadian public has become increasingly aware of the presence of these chemicals in the environment, and there is growing concern about their possible negative health effects.
  Étude des liens entre l...  
Or, certains contaminants environnementaux comme le bisphénol A (BPA) et les phtalates peuvent perturber l’action de ces hormones, d’où leur appellation de « perturbateurs hormonaux (ou endocriniens) ».
Metabolic dysfunction is a term used to describe an impairment in how the body uses and stores energy and can be associated with higher rates of obesity and diabetes. Obesity and type-2 diabetes have been steadily rising in the Canadian population (and in other countries as well), and it is suspected that prenatal exposure to environmental contaminants is a contributing factor. These two diseases are metabolic in nature, affecting both fat metabolism and carbohydrate (sugar) metabolism. A feature common to both these metabolic processes is the involvement of specific hormones. Certain environmental contaminants, such as bisphenol A (BPA) and phthalates, can potentially disrupt these hormones and are thus referred to as “hormone (or endocrine) disruptors”. BPA is used to make a hard, clear plastic and may also be found in epoxy resin linings on the inside of metal-based food and beverage cans. Thermal papers such as receipts and tickets may also be a source of BPA. Phthalates are a family of chemicals commonly used to make plastics soft and flexible and harder to break. They are often called plasticizers and have a large number of industrial and commercial uses – for example, vinyl flooring, adhesives, detergents, automotive plastics, some children’s toys, and personal-care products (soaps, shampoos, hair spray, nail polishes). Some phthalates are also used as solvents for other materials. Given the widespread use of BPA and phthalates, the Canadian public has become increasingly aware of the presence of these chemicals in the environment, and there is growing concern about their possible negative health effects.
  Étude des liens entre l...  
Or, certains contaminants environnementaux comme le bisphénol A (BPA) et les phtalates peuvent perturber l’action de ces hormones, d’où leur appellation de « perturbateurs hormonaux (ou endocriniens) ».
Metabolic dysfunction is a term used to describe an impairment in how the body uses and stores energy and can be associated with higher rates of obesity and diabetes. Obesity and type-2 diabetes have been steadily rising in the Canadian population (and in other countries as well), and it is suspected that prenatal exposure to environmental contaminants is a contributing factor. These two diseases are metabolic in nature, affecting both fat metabolism and carbohydrate (sugar) metabolism. A feature common to both these metabolic processes is the involvement of specific hormones. Certain environmental contaminants, such as bisphenol A (BPA) and phthalates, can potentially disrupt these hormones and are thus referred to as “hormone (or endocrine) disruptors”. BPA is used to make a hard, clear plastic and may also be found in epoxy resin linings on the inside of metal-based food and beverage cans. Thermal papers such as receipts and tickets may also be a source of BPA. Phthalates are a family of chemicals commonly used to make plastics soft and flexible and harder to break. They are often called plasticizers and have a large number of industrial and commercial uses – for example, vinyl flooring, adhesives, detergents, automotive plastics, some children’s toys, and personal-care products (soaps, shampoos, hair spray, nail polishes). Some phthalates are also used as solvents for other materials. Given the widespread use of BPA and phthalates, the Canadian public has become increasingly aware of the presence of these chemicals in the environment, and there is growing concern about their possible negative health effects.