gezonde – Traduction – Dictionnaire Keybot

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source	Naar een gezonde werkomgeving: het ontwikkelen en testen van interventies in de strijd tegen HIV- en tuberculosestigmatisering bij het gezondheidspersoneel in de Free State provincie, Zuid-Afrika.
Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire	Towards a health-enabling working environment: developing and testing interventions to decrease HIV- and TB-stigma among healthcare workers in the Free State Province, South Africa.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source	Opsporen van balans strategieën tijdens het stappen bij gezonde volwassenen, patiënten met een vestibulair deficit en patiënten na een cerebrovasculair accident.
Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire	Identification of gait adaptability strategies in healthy adults, patients with vestibular dysfunction and stroke patients.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Om de hypothese te staven dat een verschillende verdeling van DC subtypes en/of functie bijdraagt tot een verstoring van de regulatie van de balans tussen immuniteit en tolerantie, zullen we zowel aantal, fenotype als functie van DC in het perifeer bloed van MS-patiënten en gezonde individuen bepalen.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

To date, knowledge with regard to the distribution of myeloid and plasmacytoid dendritic cells in the circulation of MS patients is lacking. To support the hypothesis that a disturbance in the distribution of DC subtypes and/or DC function contributes to an imbalance in the regulation of immunity and tolerance, the number, phenotype and function of DC in the peripheral blood of MS patient and healthy controls will be determined.

  Neurowetenschappen - On...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Deze experimenten lopen op gezonde dieren (om in vivo een beter beeld te krijgen van de overleving, migratie en functie van autologe en allogene adulte stamcellen) en ziekte- en letselmodellen (om mogelijke therapeutische toepassingen van stamcellen te evalueren).

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

MRI and bioluminescence imaging allow the study of transplantation effects over time in small animal models, by visualizing and quantifying endogenous and externally administered stem cell recruitment in rodents and songbirds in vivo. These experiments are performed both in healthy animals to gain better insight into the survival, migration and function of autologous and allogeneic adult stem cells in vivo, and in disease and injury models to assess the potential therapeutic use of stem cells.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Om een betere differentiatie van interfererende factoren toe te laten worden ook gezonde vrijwilligers van verschillende leeftijdscategorieën en met verschillende risicoprofielen voor coronarialijden in het onderzoek betrokken.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

In this study, the effect of exercise on the number and function of circulating endothelial progenitor cells (EPC), is evaluated in chronic heart failure patients. A single bout of maximal exercise as well as a physical training program are investigated as stimuli for the release of EPC. Underlying physiological mechanisms are assessed and special attention goes to homing factors, nitric oxide and oxidative stress. Healthy subjects and patients with coronary artery disease will serve as a control group.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

In dit project wordt naar genen gezocht betrokken bij ouderdomsslechthorendheidn lawaai-geïnduceerde doofheid en otosclerose. Via een genoom-wijde associatiestudie worden bij aangetaste en gezonde proefpersonen honderdduizenden genetische varianten bepaald.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

The objective of this project is to find genes involved in age-related hearing impairment, nloise-induced hearing loss and otosclerosis. In a genome-wide association study, affected and non-affected persons are genotyped for hundred thousends of genetic variants across the entire genome. These variants are tested for association with the affection status. Apart from classical statistical tests, we will apply new analysis methods that are only possible if whole genome data are available.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Dit doctoraatsproject omvat bijgevolg drie belangrijke delen: (1) kwantitatieve analyse van endotoxines en transitie metalen in de lucht; (2) gedetailleerde mechanistische studie in cellulaire modellen voor de bepaling van de bijdrage van endotoxines en transitie metalen bij inflammatie gerelateerd aan fijn stof (3) validatie van de bevindingen bij gezonde vrijwilligers door analyse van de responsen op RNA niveau na natuurlijke blootstelling aan fijn stof bij nasale stalen.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

Urbanization has resulted in health-threatening concentrations of air pollutants like particulate matter (PM), a diverse and complex mixture of air-suspended particles. PM affects more people than any other pollutant, and can be associated with e.g. asthma exacerbations and heart and vascular diseases. Studies indicate that many of the observed health effects are related to the capacity of inhaled PM to induce airway inflammation. Although not extensively studied and often neglected in PM sample collection methods, microbial endotoxins are components of PM with naturally high inflammatory potential. This response may be further enhanced with co-exposure to the other pollutants of PM. It has been suggested that transition metals may have a synergistic effect, however, novel approaches are needed to provide information on the biologically reactive state of the metals. This doctoral project therefore aims to develop and validate biologically relevant methods for analysis of airborne endotoxins and transition metals.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Dit onderzoek richt zich op het zoeken naar nieuwe biomerkers voor deze aandoening die gemeten kunnen worden door middel van niet-invasieve staalname. Hiervoor wordt gebruik gemaakt van de differentiële analyse van proteïnen in speeksel, nasale lavage matrix en uitgeademende lucht condensaat bij astmapatiënten en gezonde controlepersonen.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

Asthma is a chronic disease of the airways that is common in young children. For the moment diagnosis of this disease is not possible under the age of 6. This project focuses for new biomarkers for asthma that can be detected in non-invasive matrices. To accomplish this, differential analysis of proteins will be assessed in saliva, nasal lavage fluid and exhaled breath condensate in asthma patients and healthy controls. Because of the non-invasive way of sampling, a diagnostic test based on the new biomarkers can be used on children, but is also more ethical for adults.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Via prospectief longitudinaalonderzoek naar het voorkomen van Mycoplasma fermentans, Mycoplasma hominis and Mycoplasma penetrans dmv P CR in 50 CFS patiënten, 50 gezonde controles uit dezelfde leefomgeving en 50 chronisch vermoeide patiënten, die niet lijden aan CFS wordt gezocht naar prevalenties, alsook correlaties tussen klinisch beeld en PCR resultaat.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

The etiology of the Chronic Fatigue Syndrome(CFS) remains unclear; infectious agents like Mycoplasma species have been proposed to play a role. In a prospective longitudinal study of a limited number of CFS patients(n=50), an equal number of healthy controls living in the same area and 50 patients with a CFS-Iike clinical picture, prevalence of Mycoplasma fermentans, Mycoplasma hominis and Mycoplasma penetrans is investigated by P CR. Correlations between clinical picture and laboratory results will be studied.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Nieuwe modellen van het menselijke hoofd zullen worden gemaakt d.m.v. statistische analyse, verschillende types materialen en elektrodes zullen worden vergeleken en de druk die door de headset wordt uitgeoefend op het hoofd zal worden gesimuleerd om een optimaal ontwerp te bekomen, dat toegevoegde waarde zal genereren voor alle betrokken partijen. Dit ontwerp zal dan geproduceerd worden en geëvalueerd door een groep gezonde testpersonen, waarna het zal gevalideerd worden door ALS-patiënten.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

The goal of this project is to find the requirements for the design of a comfortable, wirelessly operating EEG headset which will be a first step towards medically approved EEG-BCI devices that can be used to communicate by patients and support clinicians in the diagnosis of patients suffering from brain disorders. New ways to model the human head will be researched using statistical analysis, different types of materials and electrodes will be compared and simulations of pressure exerted by the headset will be made in order to achieve an optimal design, which will provide an added value for all involved stakeholders. This design will then be produced and evaluated by a test panel of healthy subjects, after which it will be validated by patients suffering from ALS.

  nieuws - Universiteit A...  

Montrer texteMontrer source en cacheMontrer URL avec texte source	Onderzoek van UAntwerpen naar de 'beestjes' in de neus van gezonde mensen leert wetenschappers meer over de aanpak van luchtwegeninfecties.
Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire	The GCE wants to play a leading role at University of Antwerp in the transition towards more sustainable mobility.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Dit onderzoeksproject stelt een geïntegreerde aanpak voor om the genetische etiologie van FTLD verder te ontrafelen. Hiertoe zullen we gecentraliseerde biobank opbouwen van humane weefsels en lichaamsvloeistoffen afkomstig van medisch en moleculair sterk gekarakteriseerde FTLD patiënten alsook van gezonde personen.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

In the past decade remarkable advances have been made in understanding the origin of frontotemporal lobar degeneration (FTLD), after Alzheimer's disease one of the leading causes of dementia. In sharp contrast however, is the absence of any therapeutic strategy based on these novel discoveries and the fact that a significant portion of patients remains in which the source of the disease is still unknown. This research project proposes an integrated approach to further uncover the genetic etiology of FTLD. This includes the establishment of a centralized repository of tissues and biofluids from medically and molecularly thoroughly characterized, extended collections of FTLD patients and unaffected individuals (biobank). This powerful biobank will allow the set-up of state of the art genetic studies of FTLD. We will participate to international large scale genome-wide association studies aiming to discover genetic risk factors for FTLD. We will further investigate these findings in our population of Flanders- Belgian FTLD patients to examine population-specific risk profiles. Moreover, the biobank will facilitate translation of knowledge obtained from these basic molecular research studies into clinical applications for improved diagnosis and treatment of future patients.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Terwijl het de klinische consequenties van sommige varianten eenduidig zijn, kunnen anderen aanwezig in zowel ogenschijnlijk gezonde en ernstig gestoord familieleden zijn, wat aangeeft dat disease modifying varianten een rol in de klinische presentatie spelen.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

Today, technologies exist that are able to screen complete human genomes for genetic defects, hereby producing massive amounts of data. These techniques include microarrays for the detection of duplicated or missing genomic material and next-generation sequencing for the detection of variation at the nucleotide level. In parallel, extensive public resources contain additional biological information on the observed variation to aid in interpretation of the data. While some variants show full penetrance, others can be present in both seemingly healthy and severely impaired family members, indicating that disease modifying variants play a role in the clinical presentation. This led to the formulation of a 'many genes, common pathways' paradigm. To study genetic variation under this paradigm, novel models placing interpretation of individual results in a context of multiple patients are mandatory. Searching for common patterns over large patient cohorts might identify recurrently affected pathways with a critical role in the studied disease. Simultaneously considering multiple variants affecting such a pathway will thus help to explain both the observed phenotype and combined with pedigree information, the intrafamilial variability. Here, we will investigate how we can apply state-of-the-art data mining methods to reveal hidden relationships between variants, with the goal of gaining new insights in the molecular pathology of heritable diseases, focusing on cognitive disorders.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Tevens is er klinisch bewijs van een gewijzigde scapula positionering en bewegingspatroon tijdens een elevatie taak van de schouder bij patiënten met nekklachten in vergelijking met gezonde proefpersonen.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

;Neck pain is one of the three most commonly reported musculoskeletal complaints, with point prevalence's varying between 10% and 22%. The lifetime prevalence has been estimated to be between 67% and 71% indicating that approximately two-thirds of all individuals will experience an episode of neck pain at some time during life. Several alterations in scapulothoracic muscle activity has been reported in patients with neck pain. In addition, there is clinical evidence that scapular position at rest and scapular motion during elevation of the upper limb may be altered in individuals with neck pain when compared to a healthy population. However, the literature clearly lacks a comprehensive studying of this relationship between scapular dysfunctions and neck pain. These insights may contribute to the rationale for the development of new therapeutic and/or preventive interventions. Therefore, the general purpose of this study is to obtain an understanding in the movement of the scapula in patients with neck pain in comparison to healthy controls. This leads to the following research questions: Do subjects with neck pain have a different movement pattern of the scapula compared to asymptomatic control subjects? and which variables affect scapular movement in neck pain patients? Consequently, patients with grade II neck pain according to the Classification of The Bone and Joint Task Force on Neck Pain and matched controls will be enrolled in this study. Pain and function will be evaluated with a Visual Analogue Scale, Neck Disability Index, Neck Bournemouth Questionnaire and CROM for cervical range of motion. The movement of the scapula will measured with the Polhemus 3SPACE FASTRAK, in order to register three scapular motions: posterior tilting (X-axis), upward rotation (Y-axis) and external/internal rotation (Z-axis).

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Op basis van de bevindingen van het validiteitsonderzoek, zullen we een experimenteel vergelijkend onderzoek uitvoeren bij drie groepen: 1. patiënten met een milde cognitieve beperking (MCI); 2. patiënten met milde dementie als gevolg van de ziekte van Alzheimer; 3. een gezonde controlegroep. De onderzoeksmethode die we hierbij gebruiken is toetsregistratie (keystroke logging).

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

Research has shown that Alzheimer (AD) patients manifest deterioration in language production. This research project aims to develop complementary screening tasks that enable researchers and clinicians to characterize the longitudinal decline of on-line written language production in AD . These aims will be addressed in three consecutive studies: 1. a task-validity study, 2. a cross-sectional study, and 3. a longitudinal study. Since findings from previous research indicate the need for a screening task that assesses multiple components of language, we will combine writing tasks that focus on motor and cognitive and linguistic aspects. The more general screening tasks (i.c., describing two pictures depicting a situation) that focus on the cognitive and linguistic aspects need to be validated first. The quality of the elicitation, and consequently of the screening tool, will benefit from a careful validation of the tasks at hand. Based on the findings of the task validity study, we will design an experimental cross-sectional study involving patients with mild cognitive impairment (MCI), mild AD and a healthy control group. The observation method used, keystroke logging, is non-intrusive, time-saving, and hence cost-reducing, when compared to other diagnostic tools. Finally, in a longitudinal study, the cross-sectional study will be replicated twice (after 6 and 12 months) in order to document the (potential) gradual cognitive decline.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Het hormoon oestrogeen heeft een neuroprotectieve functie in de hersenen.Daarom is oestrogeenproductie in de hersenen en het ovarium belangrijk voor gezonde hersenen.Het enzym cytochroom P450 aromatase is een belangrijk enzym in de biosynthese van oestrogeen, dat de omzetting van androgenen in oestrogeen katalyseert in neuronen en astrocyten.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

The hormone estrogen has neuroprotective function in the brain. Thus synthesis of estrogen in the brain and ovaries is important for healthy brain functioning. The cythorome P450 aromatase, a key enzyme in the biosynthetic pathway of estrogen, catalyzes the conversion of androgens to estrogen in neurons and activated astrocytes. Aromatase inhibitors are commonly used to treat women with invasive estrogen receptor positive breast cancer. In these patients, however, diminished estrogen levels have been linked with cognitive decline and an increased risk for developing Alzheimer's disease. How aromatase inhibition relates to cognitive dysfunction and AD needs to be investigated. The association between aromatase activity, estrogen level and cognitive performance is complicated and is not completely understood. The aim of this study is to assess how aromatase inhibitors affect the functional and structural network organization of the brain via resting state functional magnetic resonance imaging (MRI) and diffusion tensor imaging. Both of these MRI techniques provide significant information into brain function in disease and health and into the effects of interventions in functional and structural networks.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Daarnaast zullen melkzuurbacteriën (MZB) uit deze niche geïsoleerd worden en genetisch en functioneel gekarakteriseerd worden naar niche-specifieke en probiotische eigenschappen en zal hun aandeel en activiteit vergeleken worden met meer pathogene species zoals Corynebacterium en Staphylococcus. Hierbij zullen stalen van patiënten met chronische rhinosinusitis de belangrijkste focus vormen en zullen deze stalen vergeleken worden met stalen van gezonde individuen.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

Recent studies indicate that various disorders of the upper respiratory tract (URT) involve an imbalance of the microbiota in this niche, without the clear dominance of a single pathogenic species. These studies highlight that the microbial ecology of these niches needs to properly studied for a better understanding of the pathogenesis of these URT diseases. However, many details on these microbial imbalances need to be unraveled. Therefore, this project aims to characterize the microbiome in the URT by Illumina MiSeq microbial community profiling using the 16S rRNA gene as main target. In addition, we will screen for niche-specific lactic acid bacteria (LAB) as potential beneficial and probiotic microbes and we will compare their occurrence, genetic potential and functional activity with more pathogenic species such as Corynebacterium and Staphylococcus aureus. Chronic rhinosinusitis (CRS), a common URT disease, is chosen as important case-study to unravel the microbiome of the URT. Samples of CRS patients will be functionally and quantitatively compared with healthy individuals.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source	Kleine 'heat shock' proteïnen in gezonde omstandigheden en bij ziekte.
Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire	Small heat shock proteins in healthy conditions and in disease.

  Kerncompetenties - Univ...  

Montrer texteMontrer source en cacheMontrer URL avec texte source	18. De master promoot een gezonde levensstijl.
Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire	18. The master promotes a healthy lifestyle.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

De methodologie om pyridinoline cross-links in serum te bepalen wordt verder geëvalueerd en specifieke referentiewaarden zullen worden opgesteld voor een gezonde populatie en de groep met chronisch nierfalen (verminderde renale clearance van de cross-links).

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

In the clinical part of this study the following markers of bone metabolismare studied : 1) bone specific alkaline phosphatase to evaluate bone formation and 2) pyridinolin cross-links to evaluate bone breakdown. Three populations in whom the evaluation of bone metabolism is of clinical importance are included : malignant tumors (bone metastasis), chronic renal failure (secondary hyperparathyroidism, adynamic bone disease) and multipel myeloma (enhanced bone breakdown, inhibited bone formation). The methodology to determine pyridinolin cross-links in serum will be further evaluated and specific reference values will be calculated for a healthy population and for the chronic renal disease group (decreased renal clearance of the cross-links). The experimental part of this study will examine the production of pyridinolin cross-links by human bone cells in culture.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

In gezondheidseconomische evaluatie, zoals toegepast in dit rapport, wordt hetgeen het grootste voordeel is voor onze maatschappij gedefinieerd als de combinatie van interventies die leiden tot de grootste mogelijke gezondheidswinst, voor zoveel mogelijk mensen (d.i. het maximaliseren van de gezondheidswinst (hier hoofdzakelijk uitgedrukt als levensjaren en "voor kwaliteit van leven aangepaste levensjaren" of "gezonde levensjaren" (Quality Adjusted Life Year, QALY)), gegeven een beperkt budget.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

In this report, a simulation model was used to help understand the implications of deciding on the use of the currently available oral rotavirus vaccines (Rotarix® and RotaTeq®) to our greatest advantage. In health economic evaluation, as applied in this report, what is to our society's greatest advantage is defined as the combination of interventions leading to the greatest possible health gains, for as many people as possible (i.e. maximization of health gains (expressed here mainly as life years and Quality-Adjusted Life-Years (QALYs gained)), under a given budget constraint. We have reviewed the international published and unpublished literature, and collected and analyzed a wide range of Belgian epidemiological and cost data. A simulation model was developed, parameterized and fitted by using scientifically validated data, as much as possible from Belgian sources. Simulations were performed to estimate how effective and cost-effective universal rotavirus vaccination of Belgian children would be.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

In het kader van dit project willen we biologisch materiaal zoals DNA, serum, plasma en hersenmateriaal verzamelen van een grote groep Belgische frontotemporale dementie patiënten samen met uitgebreide klinische en pathologische informatie. Om genetische bevindingen van deze patiënten te kunnen vergelijken met de gezonde populatie, zullen we tevens neurologisch gezonde individuen verzamelen uit dezelfde geografische regio.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

The aim of this research project is to assemble an extended, well-documented collection of biologic material from patients with frontotemporal lobar degeneration (FTLD) in Belgium. FTLD is after Alzheimer's disease an important form of dementia. In the frame of this project we will collect biologic material including DNA, serum, plasma, brain material from a large group of Belgian FTLD patients together with extended clinical and pathologic information of these patients. In order to be able to compare genetic findings from patients with the healthy population, neurologically normal aged individuals are assembled from the same geographical region. This project will allow us to compare genetic changes across the entire genome between FTLD patients and neurologically normal individuals to study if some of these changes are more frequent in patients than in normal individuals. This approach is called genome-wide association (GWA) studies. The extended clinical, pathological and biologic information we will collect, combined with whole-genome information obtained from GWA studies will increase our understanding of the disease mechanisms leading to FTLD. These insights will lay the groundwork for a better and early diagnosis, prevention and therapy of this deadly disease.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source	INTER-ACT studie: coaching tussen zwangerschappen voor een gezonde toekomst
Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire	INTER-ACT study: Inter-pregnancy coaching for a healthy future.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Door gebruik te maken van modellen die op een gecombineerde bepaling van deze eiwitten gebaseerd zijn, wordt een hoge diagnostische nauwkeurigheid van meer dan 80% behaald en kan AD onderscheiden worden van andere vormen van dementie. Aangezien deze modellen nog niet gevalideerd zijn, hebben we een prospectieve studie opgezet waarin patiënten met dementie, milde cognitieve tekorten en gezonde ouderen zullen worden ingesloten.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

Diagnosis of sporadic Alzheimer's disease (AD) is based on clinical exclusion criteria and the required diagnostic work-up is time-consuming and expensive at best resulting in a diagnosis of probable AD. In specialized centers, a diagnostic accuracy of maximally 68% is obtained. Besides, diagnosis is only definite on post-mortem neuropathological examination of the brain. Therefore, validated biological markers allowing diagnosing AD at an early stage of the disease are highly desirable. In AD, several proteins accumulate in the brain. As the cerebrospinal fluid (CSF) is in close contact with the brain, those proteins can be detected in the CSF. Using biomarker-based models, a combined assessment of CSF levels of β-amyloid peptide (Aβ1-42), total tau protein (T-tau) and tau phosphorylated at threonine 181 (P-tau181P) increases discriminatory power allowing differentiating AD from other dementias. As this combined assessment using newly developed biomarker-based models has not been validated and as its discriminatory power and its added diagnostic value remain to be established, we set up a prospective study, including dementia (n=800) and MCI (n=200) patients as well as healthy control subjects (n=200). As Aβ isoforms can be detected in plasma, diagnostic accuracy for (early) AD diagnosis will be tested as well.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source	De reactogeniciteit en immunogeniciteit van een gecombineerd hepatitis A en B vaccin wordt onderzocht, bij een populatie van jonge gezonde volwassenen.
Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire	A clinical trial with a combined hepatitis A and B vaccine is carried out in order to examine the immunogenicity and reactogenicity of this candidate vaccine.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source	Klinische studie over het hepatitis B vaccin dat 20 mcg HBsAg op SBAS-4 bevat per 0,5 ml dosis bij gezonde adolescenten en volwassen vrijwilligers die positief zijn voor het HLA-DQ2 type.
Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire	A clinical study to compare the immunogenicity, safety and reactogenicity of SmithKline Beecham Biologicals novel adjuvanted hepatitis B vaccine.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

In het kader van dit project willen we biologisch materiaal zoals DNA, serum, plasma en hersenmateriaal verzamelen van een grote groep Belgische frontotemporale dementie patiënten samen met uitgebreide klinische en pathologische informatie. Om genetische bevindingen van deze patiënten te kunnen vergelijken met de gezonde populatie, zullen we tevens neurologisch gezonde individuen verzamelen uit dezelfde geografische regio.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

The aim of this research project is to assemble an extended, well-documented collection of biologic material from patients with frontotemporal lobar degeneration (FTLD) in Belgium. FTLD is after Alzheimer's disease an important form of dementia. In the frame of this project we will collect biologic material including DNA, serum, plasma, brain material from a large group of Belgian FTLD patients together with extended clinical and pathologic information of these patients. In order to be able to compare genetic findings from patients with the healthy population, neurologically normal aged individuals are assembled from the same geographical region. This project will allow us to compare genetic changes across the entire genome between FTLD patients and neurologically normal individuals to study if some of these changes are more frequent in patients than in normal individuals. This approach is called genome-wide association (GWA) studies. The extended clinical, pathological and biologic information we will collect, combined with whole-genome information obtained from GWA studies will increase our understanding of the disease mechanisms leading to FTLD. These insights will lay the groundwork for a better and early diagnosis, prevention and therapy of this deadly disease.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

Het humaan amnionvlies wensen wij te begruiken als cultuur bodem waarop regenertaie van eilandjes van gezonde conjunctiva kan plaatsvinden en meer in het bijzonder van conjunctivale epitheel cellen zodat deze opnieuw bekwaam is om mucine aan te maken vanuit gegenereerde goblet cells, onontbeerlijk om de traanfilm aan het corneaal oppervlak te hechten.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

The conjunctiva is a thin membrane, which covers the white part of the eye and the inside of the eyelids. It is essential that this membrane functions correctly as it plays an important role in the maintenance of a healthy ocular surface and the preservation of vision. In some ocular disorders, the conjunctiva is damaged resulting in excessive scarring leading to surface disorders such as severe dry eyes, eyelid distortions and eventually blindness. Current treatment strategies for conjunctival reconstruction include surgically removing the diseased tissue and placing a human amniotic membrane over the bare sclera to aid in tissue regeneration. However, at times either due to the nature of the diseased environment, or a lack of properly functioning conjunctival stem cells, there is aberrant wound healing with scar formation, worsening the outlook for ocular reconstruction. In this project, we address this issue by creating a cellularized conjunctival substitute that can be transplanted onto the ocular surface following debridement of diseased tissue. This approach intends to reduce/eliminate scar formation and facilitate regeneration by providing a functional conjunctival replacement containing both mucin producing goblet cells to stabilize the tear film as well as conjunctival epithelial cells to establish a barrier to infectious microbes. The human amniotic membrane will be investigated as a biological scaffold for cultivating the cellular grafts for this purpose.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source	Een dubbelblinde fase II proef om de immunogeniciteit voor het (samengestelde ) Hib vaccin te bepalen bij gebruik als een eerstelijns vaccinatie bij gezonde kinderen op de leeftijd van 3, 4 en 5 maanden.
Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire	A double blind phase II trial to compare the immunogenicity of Hib conjugate vaccine as a primary vaccination course in healthy infants at 3, 4 and 5 months of age.

  Onderzoek - Universitei...  

Montrer texteMontrer source en cacheMontrer URL avec texte source

In het kader van dit project willen we biologisch materiaal zoals DNA, serum, plasma en hersenmateriaal verzamelen van een grote groep Belgische frontotemporale dementie patiënten samen met uitgebreide klinische en pathologische informatie. Om genetische bevindingen van deze patiënten te kunnen vergelijken met de gezonde populatie, zullen we tevens neurologisch gezonde individuen verzamelen uit dezelfde geografische regio.

Comparer pages textesComparer pages HTMMontrer URL avec texte sourceMontrer URL avec langue cibleDéfinir uantwerpen.be comme domaine prioritaire

The aim of this research project is to assemble an extended, well-documented collection of biologic material from patients with frontotemporal lobar degeneration (FTLD) in Belgium. FTLD is after Alzheimer's disease an important form of dementia. In the frame of this project we will collect biologic material including DNA, serum, plasma, brain material from a large group of Belgian FTLD patients together with extended clinical and pathologic information of these patients. In order to be able to compare genetic findings from patients with the healthy population, neurologically normal aged individuals are assembled from the same geographical region. This project will allow us to compare genetic changes across the entire genome between FTLD patients and neurologically normal individuals to study if some of these changes are more frequent in patients than in normal individuals. This approach is called genome-wide association (GWA) studies. The extended clinical, pathological and biologic information we will collect, combined with whole-genome information obtained from GWA studies will increase our understanding of the disease mechanisms leading to FTLD. These insights will lay the groundwork for a better and early diagnosis, prevention and therapy of this deadly disease.