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Keybot 12 Results  www.uantwerpen.be
  Onderzoek - Universitei...  
VIB-Follow-up van genoom-wijde associatiestudies in a krachtige studiepopulatie van Belgische FTLD patiënten.
VIB-Follow-up of genome-wide association studies in a powerful study population of Belgium FTLD patients.
  Onderzoek - Universitei...  
Een genoom-wijde zoektocht naar een gen voor erfelijke distale motorische neuropathie.
A genome-wide search for the distal hereditary motor neuropathy gene.
  Onderzoek - Universitei...  
In dit project wordt naar genen gezocht betrokken bij ouderdomsslechthorendheidn lawaai-geïnduceerde doofheid en otosclerose. Via een genoom-wijde associatiestudie worden bij aangetaste en gezonde proefpersonen honderdduizenden genetische varianten bepaald.
The objective of this project is to find genes involved in age-related hearing impairment, nloise-induced hearing loss and otosclerosis. In a genome-wide association study, affected and non-affected persons are genotyped for hundred thousends of genetic variants across the entire genome. These variants are tested for association with the affection status. Apart from classical statistical tests, we will apply new analysis methods that are only possible if whole genome data are available.
  Onderzoek - Universitei...  
De mijlpalen van dit project zijn: - Uitbouw van biobank - Identificatie van kandidaatgenen voor hoogbegaafdheid via een genoom-wijde associatiestudie - Associatiestudies tussen hoogbegaafdheid en cognitie-gerelateerde genen - De studie van de relatie tussen "copy number variations" (CNV) en hoogbegaafdheid
The aim of the project is to initiate molecular genetics/genomics research of giftedness in children starting from the unique population collected by CBO. The milestones of this project are: - Construction of a bio bank - Identification of candidate genes for giftedness using a SNP based whole genome association approach - Association studies for giftedness and cognition related genes - Determination the involvement of copy number variations (CNVs) in the etiology of giftedness
  Onderzoek - Universitei...  
De mijlpalen van dit project zijn: - Uitbouw van een biobank voor hoogbegaafdheidsonderzoek ¿ Identificatie van kandidaatgenen voor hoogbegaafdheid via een SNP gebaseerde genoom¿wijde associatiestudie ¿ De studie van de relatie tussen copy number variaties (CNVs) en hoogbegaafdheid
The aim of the project is to initiate and perform state of the art molecular genetics/genomics research on giftedness in children starting from the large and unique population collected by CBO. The milestones of this project are: ¿ Construction of a bio bank for giftedness research ¿ Identification of candidate genes for giftedness using a SNP based whole genome association approach ¿ Determination of the involvement of copy number variations (CNVs) in the etiology of giftedness
  Onderzoek - Universitei...  
In dit project wordt naar genen gezocht betrokken bij ouderdomsslechthorendheidn lawaai-geïnduceerde doofheid en otosclerose. Via een genoom-wijde associatiestudie worden bij aangetaste en gezonde proefpersonen honderdduizenden genetische varianten bepaald.
The objective of this project is to find genes involved in age-related hearing impairment, nloise-induced hearing loss and otosclerosis. In a genome-wide association study, affected and non-affected persons are genotyped for hundred thousends of genetic variants across the entire genome. These variants are tested for association with the affection status. Apart from classical statistical tests, we will apply new analysis methods that are only possible if whole genome data are available.
  Onderzoek - Universitei...  
Deze krachtige biobank zal toelaten om state- of- the-art genetische studies van FTLD uit te voeren, waaronder het deelnemen aan internationale grootschalige genoom-wijde associatie studies (GWAS) op zoek naar genetische risico factoren voor FTLD.
In the past decade remarkable advances have been made in understanding the origin of frontotemporal lobar degeneration (FTLD), after Alzheimer's disease one of the leading causes of dementia. In sharp contrast however, is the absence of any therapeutic strategy based on these novel discoveries and the fact that a significant portion of patients remains in which the source of the disease is still unknown. This research project proposes an integrated approach to further uncover the genetic etiology of FTLD. This includes the establishment of a centralized repository of tissues and biofluids from medically and molecularly thoroughly characterized, extended collections of FTLD patients and unaffected individuals (biobank). This powerful biobank will allow the set-up of state of the art genetic studies of FTLD. We will participate to international large scale genome-wide association studies aiming to discover genetic risk factors for FTLD. We will further investigate these findings in our population of Flanders- Belgian FTLD patients to examine population-specific risk profiles. Moreover, the biobank will facilitate translation of knowledge obtained from these basic molecular research studies into clinical applications for improved diagnosis and treatment of future patients.
  Onderzoek - Universitei...  
De Genetische Service Faciliteit (GSF) is een centrale kernfaciliteit in het VIB Departement voor Moleculaire Genetica die aan de onderzoekers snel en professioneel, hoge doorvoer genetische analyses aanbiedt via een robotica platform. De aangeboden diensten omvatten onder meer DNA/RNA extracties, DNA sequenties, geno-typeringen van genetische merkers in patiënten/controle groepen en genoom-wijde segregatieanalyses in families.
The Genetic Service Facility (GSF) is a central core facility in the VIB Department of Molecular Genetics that offers its researchers via a robotic platform different genetic analysis such as DNA/RNA extractions, DNA sequencing, SNP genotyping and genome-wide STR linkage analyses. Hereto, the GSF is equipped with 1 Biomek FX and 2 Biomek NX robot platforms (Beckman) for automatic pre- and post processing of samples, three 3730XL capillary sequencers (Applied Biosystems) for DNA sequencing and STR genotyping, a SEQUENOM platform for high-throughput mass array spectrometric SNP genotyping. More recently, the GSF has also acquired an ABI5500xl SOLiD for high-throughput next generation sequencing within divers applications. Also the isolation of DNA and RNA from various sources is centralized in the GSF using Magtration System8Lx and Magtration 12GCplus systems as well as the production of EBV transformed lymphoblast cell lines. With an optimized database system LIMS (Laboratory Information Management System) and the use of Electronic Lab Notebooks (ELN) in a Good Laboratory Practice (GLP) environment the majority of data processing is performed automatically and in optimal conditions. Because of the recognition by the University of Antwerp and the VIB of the GSF as a centralized core facility, their scientists can now make use of the genetic and genomic services at marginal cost.
  Onderzoek - Universitei...  
- Controle van complexe multi-agent systemen: Een eerste doel van het project is om software en- gineering abstracties te ontwikkelen voor het systematisch programmeren van allerhande grootschalige netwerken. De ontwikkelde abstracties zullen de basis vormen om gedistribueerde lerende agenten netwerken aan te sturen op een netwerk wijde manier in plaats van agent per agent zoals in de huidige oplossingen.
The central research question of the SMILE-IT project is: "How can complex networks become self- organizing while ensuring stability and without sacrificing on performance. Moreover the decisions taken by the system should be understand- able and guidable." More precisely, the project aims to develop a framework for studying and managing modern distributed networked systems that contain a large number of entities or agents, both machine and human, which strive to achieve their personal objectives. The framework developed within the proposal will guide these entities, either through direct control or by way of incentives, in order to achieve system-wide optimal behaviour, satisfy global objectives and adhere to the system's operational constraints in the face of diverging and incompatible personal goals. Software language abstractions will be identified and developed, to support the ease of the deployment of the framework on a wide variety of networks. The framework will build on the expertise of the teams in machine learning (including game theory, self- organization of complex systems, large-scale multi-agent systems and emergent social behaviour), network management and modelling, and software language design. The key idea of the framework is that the context within which intelligent decision making components or agents operate may depend on spatial and temporal factors. As such, they should be able to adapt their behaviour and goals as a function of space and time. The framework should satisfy the following requirements: It should be generic so as to be applicable to a wide range of networks, it should be scalable with respect to the size of the network, the resulting behaviour should be (near) optimal and at all times minimal performance should be guaranteed, also in unexpected situations. Several fundamental scientific challenges remain to be solved before this high-level objective can be achieved. They can be summarized as follows: - Complex multi-agent control: The SMILE-IT project will develop programming abstractions for distributed network control, that allow agents to be configured and controlled in a network-, rather than agent-centric manner. Moreover, it will provide abstractions to efficiently query and control the state of large-scale complex networks, as reinforcement learning techniques continuously require a view on the current state of the environment. - Fast and stable convergence towards an acceptable solution: SMILE-IT aims to guara
  Onderzoek - Universitei...  
Echter, de genen die vandaag gekend zijn veroorzaken allemaal relatief zeldzamere autosomaal dominante vormen van de ziekte en laten een aanzienlijke fractie van de patiënten onverklaard (ongeveer 80%). Om hieraan tegemoet te komen werden de eerste genoom-wijde associatie (GWA) studies opgestart op zoek naar meer frequente genetische variaties die het risico op FTLD kunnen beïnvloeden.
In the past decade a lot of progress was made in elucidating the genetic and pathologic make-up of frontotemporal lobar degeneration (FTLD), one of the leading causes of dementia. The genes known to date however are implicated in the autosomal dominant forms of the disease and leave a significant fraction (about 80%) of patients as yet unresolved. Therefore the first genome-wide association (GWA) studies were initiated in search for more common genetic variants influencing risk for FTLD. An essential step in the identification of novel genetic risk factors for complex diseases is the replication and confirmation of GWA association signals in independent study populations. The aim of this research project is to provide these invaluable replication studies using a powerful, well-documented, homogenous Flanders-Belgian study population. We recently participated in a GWA of FTLD with TDP43 pathology, the major pathological subtype of FTLD. The study uncovered common genetic variation in the gene TMEM106B as a putative risk factor for FTLD-TDP. Samples to set-up a second large scale international GWA study of patients with a clinical diagnosis of FTLD, to which we contributed 256 patients, have now been collected and results of the genome-wide genotyping are expected by the end of 2010. For this research project we plan to perform in depth follow-up studies of these two GWA studies of FTLD. Hereto we will test association of the GWA top single nucleotide polymorphisms (SNPs) in our Flanders-Belgian FTLD sample; sequence candidate genes within the associated regions, saturate the loci with SNPs and define the minimal associated risk haplotype blocks by allelic, genotypic and haplotype-based association analysis; and ultimately tend to isolate the genetic variants responsible for the risk modifying effect by genomic sequencing of the minimal associated loci. A better understanding of the genes and proteins involved in the pathogenic cascade leading to FTLD will be instrumental for the development of targeted therapeutic strategies to alleviate the suffering of these patients.