wnt – -Translation – Keybot Dictionary

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In January 2011, the bill “standardization top incomes in public and semi-public sector” (WNT) has been sent to the parliament by the Minister of the Interior and Kingdom Relations (BZK) . The bill sets a limit to the remuneration of directors and top executives in the public and semi-public sectors.

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In januari 2011 is het wetsvoorstel normering bezoldiging topfunctionarissen publieke en semipublieke sector (WNT) door de minister van Binnenlandse Zaken en Koninkrijksrelaties (BZK) namens het kabinet naar de Tweede Kamer gestuurd. Het wetsvoorstel stelt een maximum aan de bezoldiging van bestuurders en hoogste leidinggevenden in de publieke en semipublieke sector. Voor de onderwijssectoren gaan sectorale beloningsmaxima gelden. De vraag is of de in het onderwijs bestaande beloningscodes hiervoor toereikend zijn. Dat hoeft niet het geval te zijn.

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Tyrosine kinase inhibitors (TKIs), the current standard of care for CML, lead to up-regulation of the CD27-ligand (CD70) on LSCs which induces therapy resistance by activating the Wnt signaling pathway.

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Der Pfizer Forschungspreis 2017 im Bereich Onkologie Grundlagenforschung geht an Dr. Christian Schürch (Institut für Pathologie) und PD Dr. Carsten Riether (Departement Klinische Forschung). Sie fanden heraus, dass der CD27 Rezeptor eine wichtige Rolle für das Überleben und die Vermehrung von Leukämie-Stammzellen (LSC) der chronischen myeloischen Leukämie (CML) spielt. Tyrosinkinase-Inhibitoren (TKI), die aktuelle Standardtherapie für CML, führen zur Hochregulation des CD27-Liganden (CD70) auf LSC und verursachen Therapieresistenz durch Aktivierung des Wnt-Signaltransduktionsweges. Eine Kombinationstherapie von TKI und anti-CD70 Antikörpern überwindet diesen Resistenzmechanismus, eliminiert die LSC und führt zur Heilung der CML im Mausmodell.

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William Tse stressed, "The exact function of AF1q in the body is not yet fully understood, and we are excited to explore this aspect further. But our study shows that AF1q is an important protein in the TCF7/Wnt signaling pathway and controls the aggessive behaviour of cancer cells."

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Die genaue Funktion von AF1q im Körper ist noch nicht vollends geklärt, aber die Studie zeigt, dass AF1q ein entscheidendes Schlüsselprotein im TCF7/Wnt-Signalweg darstellt und das Verhalten von Krebszellen steuert. Erweiterte AF1q-Expression fördert die Entstehung und das Wachstum von Tumorzellen und verhindert den natürlichen Zelltod. An Brustkrebs erkrankte Menschen mit ausgeprägter AF1q-Expression haben eine weit schlechtere Prognose als jene ohne sie. Weiters sind AF1q-„positive“ Krebszellen resistenter gegenüber Chemotherapien.

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Figure 2: Regulation of heart tube fusion by non-canonical Wnt signaling. Effects of a dominant-negative version of Dishevelled (Dvl DEP) on zebrafish heart development. Transgenic zebrafish embryos carrying mlc2a-eGFP reporter were injected with Control AP mRNA (H) or Dvl DEP mRNA (I, J) and allowed to grow for 48 h.

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Figura 2: Regulació de la fusió dels tubs del cor en la senyalització Wnt no canònica. Efectes del model dominant negatiu de dishevelled (Dvl DEP) en el desenvolupament del cor de peixos zebra. Als embrions de peix zebra transgènics portadors de la informació mlc2a-eGFP se'ls va injectar el control AP mRNA (H) o Dvl DEP mRNA (I, J) i es van deixar créixer 48 hores. La injecció de Dvl DEP fins i tot en petites concentracions (J) va provocar la formació de dos cors situats lateralment (càrdia bífida) en embrions de peixos zebra. Vistes ventrals, de l'anterior a la superior. De Matsui et al, Genes & Dev 19: 164-175; 2005.

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Tankyrase 2 was cloned out of human breast tumor as a tumor antigen [Kuimov et al., 2001, Genes Immun]. Signaling pathways Ras-MAPK and Wnt consist of products of many proto-oncogenes. Besides, the activity of tankyrase indirectly stimulates telomerase what is important for infinitive proliferation of cancer cells.

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Танкираза 2 была клонирована из опухоли молочной железы человека как опухолевый антиген [Kuimov et al., 2001, Genes Immun]. Сигнальные пути Ras-MAPK и Wnt включают целый ряд продуктов протоонкогенов. Кроме того, активность танкираз опосредованно стимулирует теломеразу, что важно для неограниченной пролиферации опухолевых клеток. Ингибиторы танкиразы разработаны фирмой Новартис и проходят испытания для применения в качестве лекарственных препаратов [Huang et al, 2009, Nature]. Этот фермент может представлять интерес для исследований рака, старения, иммортализации, стволовых клеток, а также эмбриогенеза и функционирования почек, мозга и других органов и тканей.

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Specific areas of interest include the effects of HER-2 amplification pattern and prior Herceptin/TDM-1 therapy on HER-2 expression, the therapeutic inhibition of the oncogenic Wnt/beta-catenin pathway, and targeting wild type c-KIT combination with PI3K pathway inhibition in basal-like PDXs.

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CIBOT, el Consorcio de Investigación Biomédica y Oncología Traslacional, es un programa científico establecido en colaboración con Novartis en 2013. Esta iniciativa define y desarrolla investigaciones con los objetivos siguientes: determinar los mecanismos etiopatogénicos del cáncer y desarrollar herramientas diagnósticas y terapéuticas novedosas y más eficaces; investigar el potencial terapéutico de nuevos agentes antineoplásicos, y aplicar tecnologías vanguardistas y los datos más recientes para avanzar en la investigación del cáncer. Algunas de las áreas de interés son los efectos del patrón de amplificación de HER2 y el tratamiento previo con Herceptin/TDM-1 en la expresión de HER2, la inhibición terapéutica de la vía oncogénica Wnt/β-catenina y la acción sobre la combinación c-kit wild type con inhibición de la vía PI3K en PDX de tipo basal.

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Show textShow cached sourceOpen source URL	Research is concerned with frog and mouse development and the underlying molecular mechanisms. The two focal points are cell-cell communication by Wnt signaling and epigenetic regulation by DNA demethylation.
Compare text pagesCompare HTM pagesOpen source URLOpen target URLDefine leopoldina.org as primary domain	Hauptarbeitsgebiete: Aufklärung der molekularen Mechanismen der Embryonalentwicklung beim Wirbeltier; embryonale Achsenentwicklung bei Wirbeltieren (Xenopus-Entwicklung); Kopfinduktion; Spemann-Organisator; Wnt-Signalweg; globale embryonale Genexpressionsanalyse

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Show textShow cached sourceOpen source URL	Exhibitor: Plansee, Ceratizit, WNT
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Show textShow cached sourceOpen source URL	Panel saw operator - woodworking (Selco WNT 600 Numeric Controlled Beam Panel Saw)
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Show textShow cached sourceOpen source URL	Cross-section of a mouse lung before (left) and after (right) activation of the WNT signalling pathway. Activation resulted in improved lung structure (right). Photo/Graphic: HMGU/M. Königshoff. Read more
Compare text pagesCompare HTM pagesOpen source URLOpen target URLDefine helmholtz.de as primary domain	Immunhistochemische Schnitte durch die Mäuselung vor (links) und nach (rechts) Aktivierung des WNT-Signalwegs. Foto/Grafik: HMGU/M. Königshoff.mehr lesen

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Show textShow cached sourceOpen source URL	Notum deacylates Wnt proteins to suppress signalling activity
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Show textShow cached sourceOpen source URL	Role of the canonical Wnt pathway in skeletal muscle aging (CIHR)
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Show textShow cached sourceOpen source URL	Extrinsic control of Wnt signaling in the intestine
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Show textShow cached sourceOpen source URL	Polyvalent DP1 keeps the Wnt pathway neat and tidy.
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Show textShow cached sourceOpen source URL	Hans Clevers (Hubrecht Institute): describing the role of Wnt signaling in tissue stem cells and cancer.
Compare text pagesCompare HTM pagesOpen source URLOpen target URLDefine biocat.cat as primary domain	Hans Clevers (Hubrecht Institute): descripción de la función de señalización de Wnt en células madre de tejidos y cáncer.
Compare text pagesCompare HTM pagesOpen source URLOpen target URLDefine biocat.cat as primary domain	Hans Clevers (Hubrecht Institute): descripció de la funció de senyalització de Wnt en cèl·lules mare de teixits i càncer.

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Show textShow cached sourceOpen source URL	Abnormal morphogenesis of midbrain and cerebellum in swaying, a mutantion of segment polarity gene Wnt-1
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Show textShow cached sourceOpen source URL	The agreed salary is in accordance with the Senior Officials in the Public and Semi-Public Sector (Standards for Remuneration) Act (WNT), which is expected to come into force on 1 January 2013.
Compare text pagesCompare HTM pagesOpen source URLOpen target URLDefine tudelft.nl as primary domain	Het inkomen dat is afgesproken is in overeenstemming met de Wet Normering bezoldiging Topfunctionarissen (WNT), die naar verwachting per 1 januari 2013 in werking treedt.

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Show textShow cached sourceOpen source URL	The agreed salary is in accordance with the Senior Officials in the Public and Semi-Public Sector (Standards for Remuneration) Act (WNT), which is expected to come into force on 1 January 2013.
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Show textShow cached sourceOpen source URL	Evaluation of the role of LRP4 in the regulation of Wnt/Bcatenin dependent Wnt signalling and bone formation.
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Show textShow cached sourceOpen source URL	The kinase IKKepsilon links the pro-inflammatory signature to Wnt-driven tumor development in the intestine
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